{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:15:59Z","timestamp":1783358159354,"version":"3.54.6"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Margin design significantly influences endocrown biomechanical performance. Nevertheless, long\u2010term clinical data comparing margin designs within a singular zirconia\u2010reinforced lithium silicate (ZLS) system remain scarce. This study reports the 6\u2010year follow\u2010up results of a multicenter, prospective, randomized, assessor\u2010blinded superiority trial. The trial compares CAD\/CAM ZLS endocrowns with 90\u00b0 shoulder margins and butt\u2010joint margins in endodontically treated molars (ETMs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Two hundred ETMs in 200 patients meeting the inclusion criteria were randomly restored with chairside CAD\/CAM ZLS endocrowns, which were then assigned to either the 90\u00b0 shoulder margin group or the butt\u2010joint margin group. All restorations were fabricated following a standardized digital workflow and adhesively luted in line with predefined cementation protocols. Subsequently, clinical and radiographic evaluations were performed at baseline and annually for up to 6\u2009years using modified United States Public Health Service (USPHS) criteria. Cumulative tooth survival and clinical success rates were estimated using Kaplan\u2013Meier analysis, and group comparisons were conducted using log\u2010rank tests (\n                      <jats:italic>\u03b1<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over 6\u2009years, 35 restorations failed, and 32 were censored, leaving 133 endocrowns (79 butt\u2010joint, 54 shoulder) available for clinical examination (6\u2010year recall rate 66.5%). The 6\u2010year cumulative tooth survival rate was 93.1% (91.7% butt\u2010joint vs. 94.8% shoulder). The 6\u2010year cumulative clinical success rate was 80.5% (81.4% butt\u2010joint vs. 79.4% shoulder). Restoration fractures were the most prevalent failure type, with most affected teeth remaining restorable. No statistically significant difference was found between the two margin\u2010design groups in 6\u2010year tooth survival or clinical success.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limitations of this study, both margin designs demonstrated favourable long\u2010term clinical outcomes for CAD\/CAM ZLS endocrowns in ETMs when standardized protocols were followed. The available evidence does not support the superiority of the 90\u00b0 shoulder margin over the butt\u2010joint margin. Both designs are clinically acceptable for the restoration of ETMs with CAD\/CAM ZLS endocrowns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70220","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:30:53Z","timestamp":1783355453000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter\n                    <scp>RCT<\/scp>\n                    6\u2010Year Survival of Zirconia\u2010Reinforced Lithium Silicate Endocrowns: 90\u00b0 Shoulder Versus Butt\u2010Joint Margins"],"prefix":"10.1111","author":[{"given":"Ping","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Stomatology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Stomatology Longgang Otorhinolaryngology Hospital  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liya","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2950-4969","authenticated-orcid":false,"given":"Zhongchun","family":"Tong","sequence":"additional","affiliation":[{"name":"Hosiptal of Stomatology Sun Yat\u2010Sen University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3969-3738","authenticated-orcid":false,"given":"Wenjuan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Stomatology, Nanfang Hospital Southern Medical University  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.dental.2023.11.012","article-title":"Biomechanical Behavior and Weibull Survival of CAD\u2010CAM Endocrowns With Different Marginal Designs: A 3D Finite Element Analysis","volume":"40","author":"AboElhassan R. 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