{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:04:47Z","timestamp":1784887487322,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"abstract":"ABSTRACT<\/jats:title>\n \n Introduction<\/jats:title>\n \n This study evaluated whether the\n SCN9A<\/jats:italic>\n rs6746030 (G>A; R1150W) polymorphism is associated with the clinical success or failure of pulpal anaesthesia following an inferior alveolar nerve block (IANB).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this prospective clinical genetic association study, 320 patients with symptomatic irreversible pulpitis in mandibular molars were recruited. Each patient received a standardized IANB with 2% lidocaine and 1:80000 epinephrine. Anaesthesia was considered successful if the Heft\u2010Parker Visual Analogue Scale (HP\u2010VAS) score was below 54\u2009mm during access cavity preparation\/instrumentation; scores of 54\u2009mm or higher were classified as failures. Buccal swab samples were collected for genotyping of rs6746030 using a TaqMan SNP assay. Genotype distributions were compared between the success and failure groups. Statistical analysis included Hardy\u2013Weinberg equilibrium testing, chi\u2010square comparisons, and binary logistic regression with genotype, age and gender as predictors.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Out of 320 patients analysed, 199 experienced failed anaesthesia, while 121 achieved successful outcomes. A significant deviation from Hardy\u2013Weinberg equilibrium was found in the failed anaesthesia group (\n p<\/jats:italic>\n \u2009<\u20090.05), suggesting potential genetic influence, while the successful group showed no deviation (\n p<\/jats:italic>\n \u2009=\u20090.99). Logistic regression revealed that patients with the AA genotype had significantly lower odds of successful anaesthesia (OR\u2009=\u20090.22; 95% CI: 0.049\u20130.993). No significant associations were observed for the GA genotype, age, or gender. The model's predictive ability was limited, with an AUC of 0.53.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The rs6746030 polymorphism of\n SCN9A<\/jats:italic>\n in its AA form is associated with a higher likelihood of IANB failure in mandibular molars with symptomatic irreversible pulpitis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/iej.70236","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:30:52Z","timestamp":1784885452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the\n SCN9A<\/scp>\n rs6746030 (\n R1150W<\/scp>\n ) Polymorphism on Inferior Alveolar Nerve Block Failure in Symptomatic Irreversible Pulpitis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-4554","authenticated-orcid":false,"given":"Vivek","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry & Endodontics, Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8047-5054","authenticated-orcid":false,"given":"Alpa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Manav Rachna University Faridabaad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Singla","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry & Endodontics SGT Dental College Gurgaon Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kapila","family":"Kumar","sequence":"additional","affiliation":[{"name":"Manav Rachna University Faridabaad Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9151-8536","authenticated-orcid":false,"given":"Rajinder","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry & Endodontics Guru Nanak Dev Dental College and Research Institute Sunam Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4710-0397","authenticated-orcid":false,"given":"Shahnaz","family":"Nabi","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry & Endodontics, Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1981-0516","authenticated-orcid":false,"given":"Sanjay","family":"Miglani","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry & Endodontics, Faculty of Dentistry Jamia Millia Islamia New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-7378","authenticated-orcid":false,"given":"Ikhlas","family":"El Karim","sequence":"additional","affiliation":[{"name":"School of Medicine Dentistry and Biomedical Sciences Queen's University Belfast Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jebdp.2013.04.001","article-title":"Inferior Alveolar Nerve Block With Articaine Supplemented With Articaine Buccal Infiltration Gives Better Success Rate Than Lidocaine, During Endodontic Management of Patients With Symptomatic Irreversible Pulpitis","volume":"13","author":"Aggarwal V.","year":"2013","journal-title":"Journal of Evidence\u2010Based Dental Practice"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.11607\/ofph.1642","article-title":"Comparative Evaluation of Anesthetic Efficacy of 2% Lidocaine, 4% Articaine, and 0.5% Bupivacaine on Inferior Alveolar Nerve Block in Patients With Symptomatic Irreversible Pulpitis: A Prospective, Randomized, Double\u2010Blind Clinical Trial","volume":"31","author":"Aggarwal V.","year":"2017","journal-title":"Journal of Oral & Facial Pain and Headache"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joen.2018.09.012","article-title":"Efficacy of Articaine Versus Lidocaine Administered as Supplementary Intraligamentary Injection After a Failed Inferior Alveolar Nerve Block: A Randomized Double\u2010Blind Study","volume":"45","author":"Aggarwal V.","year":"2019","journal-title":"Journal of Endodontics"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.joen.2020.11.023","article-title":"Preoperative Intraligamentary Injection of Dexamethasone Can Improve the Anesthetic Success Rate of 2% Lidocaine During the Endodontic Management of Mandibular Molars With Symptomatic Irreversible Pulpitis","volume":"47","author":"Aggarwal V.","year":"2021","journal-title":"Journal of 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