{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:27:04Z","timestamp":1786116424141,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/10222\u20104"],"award-info":[{"award-number":["2020\/10222\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate CD68 and F4\/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two Wistar rats were distributed in the following groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098): C\u2014control; AP\u2014apical periodontitis; LF\u2014liver fibrosis; APLF\u2014AP and LF. LF was induced by carbon tetrachloride administration for 8\u2009weeks and surgical bile duct ligation; AP was induced by the exposure of the dental pulp to the oral environment for 30\u2009days. Mandibles and livers were removed after euthanasia. The histological and immunohistochemical analysis of CD68 and F4\/80 glycoproteins were performed. Two\u2010way ANOVA test was used for statistical analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The livers of the LF and APLF groups showed generalised portal inflammatory infiltrate and collagen fibres, confirming the presence of LF. The immunohistochemical analysis in the liver revealed a greater number of CD68 and F4\/80 in the APLF group when compared with AP (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.05). Histopathological analysis in the mandibles of the AP and APLF groups showed areas of necrosis comprising the entire dental pulp and periapical tissue surrounded by inflammatory infiltrate. Immunohistochemical analysis showed greater immunolabelling for CD68 and F4\/80 in the APLF group than in the AP group (\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CD68 and F4\/80 glycoproteins exhibit inflammatory synergy between apical periodontitis and liver fibrosis, increasing macrophage numbers in the inflammatory processes of both diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70244","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:57:16Z","timestamp":1786010236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>CD68<\/scp>\n                    and\n                    <scp>F4<\/scp>\n                    \/80 Markers Demonstrate Inflammatory Synergism Between Apical Periodontitis and Liver Fibrosis in Wistar Rats"],"prefix":"10.1111","author":[{"given":"L. V.","family":"Barroti","sequence":"first","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4313-7149","authenticated-orcid":false,"given":"C.","family":"Cantiga\u2010Silva","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1426-2613","authenticated-orcid":false,"given":"M. P.","family":"Justo","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. H. C.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4269-7902","authenticated-orcid":false,"given":"F. D.","family":"Faria","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Goto","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-0583","authenticated-orcid":false,"given":"E.","family":"Ervolino","sequence":"additional","affiliation":[{"name":"Department of Basic Science, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8402-7408","authenticated-orcid":false,"given":"G.","family":"Sivieri\u2010Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Endodontic Section, Department of Preventive and Restorative Dentistry, School of Dentistry S\u00e3o Paulo State University (Unesp)  Ara\u00e7atuba SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2987-4759","authenticated-orcid":false,"given":"T. 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