{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:06:07Z","timestamp":1789171567541,"version":"build-2803163510"},"reference-count":54,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["HI20C2114"],"award-info":[{"award-number":["HI20C2114"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102021R1A2C2006952"],"award-info":[{"award-number":["NRF\u20102021R1A2C2006952"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102022M3A9F3082330"],"award-info":[{"award-number":["NRF\u20102022M3A9F3082330"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To prospectively compare treatment outcomes for orthograde canal obturation using Ortho MTA III (OMTA) with the continuous wave of compaction (CWC) using gutta\u2010percha (GP) and AH Plus sealer, and to identify associated predictive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Informed consent was obtained (110 patients), and single\u2010 or two\u2010rooted permanent teeth (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009120) diagnosed with pulp necrosis (or previously treated) and asymptomatic apical periodontitis or chronic apical abscess (periapical index, PAI\u2009\u2265\u20093) were randomly assigned to two groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200960\/group). The canals were prepared to a minimal apical size #40 (ISO) based on their initial file size, disinfected and obturated by either CWC or OMTA using an enhanced disinfection protocol (GP disinfected, new gloves after each intraoperative radiograph and before starting obturation). Clinical and periapical radiographic examinations were conducted by two calibrated, independent endodontists during follow\u2010up periods of at least 12\u2009months. Success rates and associated predictive factors (tooth\u2010, operator\u2010 and patient\u2010related) were analysed statistically using binary and multiple logistic regression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median recall period was 30\u2009months (14\u201348\u2009months), and 104 teeth were finally analysed (recall rate: 86.67%). No significant differences in success rate were observed between the groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05) under both loose (OMTA: 88.24%, CWC: 83.02%) and strict criteria (OMTA: 64.71%, CWC: 58.49%). Multivariate analysis revealed that age (OR\u2009=\u20095.735, 95% CI: 1.286\u201325.577,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), periapical lesion size (OR\u2009=\u20096.596, 95% CI: 1.397\u201331.138,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) and PAI score (OR\u2009=\u20092.081, 95% CI: 1.047\u20134.136,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036) were significant predictors of treatment failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Orthograde obturation of infected canals with Ortho MTA III demonstrated comparable success and treatment outcomes to those filled with GP and sealer by CWC, supporting its potential as a clinically viable alternative for the obturation of infected root canals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/cris.nih.go.kr\">cris.nih.go.kr<\/jats:ext-link>\n                      registration number: KCT00099939\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70248","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T08:05:37Z","timestamp":1786608337000},"page":"2071-2083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes and Associated Prognostic Factors for Orthograde Canal Obturation Using Ortho\n                    <scp>MTA III<\/scp>\n                    : A Randomised Prospective Clinical Trial"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4760-0475","authenticated-orcid":false,"given":"Hyo\u2010Jung","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital Seoul National University School of Dentistry  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3931-7668","authenticated-orcid":false,"given":"Yeon\u2010Jee","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital Seoul National University School of Dentistry  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6484-5932","authenticated-orcid":false,"given":"Hiran","family":"Perinpanayagam","sequence":"additional","affiliation":[{"name":"Division of Endodontics, Schulich School of Medicine &amp; Dentistry University of Western Ontario  London Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7196-5123","authenticated-orcid":false,"given":"Yoon Seon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital Seoul National University School of Dentistry  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae\u2010Hyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry, Dental Research Institute, Seoul National University Dental Hospital Seoul 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