{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:30:47Z","timestamp":1787135447106,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To characterize the translational pathway of endodontic technology from patent filing to clinical availability, with four objectives: (i) determine the grant rate and jurisdictional distribution; (ii) characterize temporal dynamics of the grant process; (iii) map distribution across technology categories; and (iv) evaluate maturity and regulatory status in a strategic subset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      A retrospective cohort of 201 patent families was identified from European Patent Office Espacenet (Cooperative Patent Classification class A61C5*), priority years 2012\u20132014. Variables included technology category, jurisdiction, granted status in the USA, Europe, and Japan, time until first grant, and patent status at 31 December 2025. A strategic subset (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), defined as families with identifiable regulatory or commercial signals, was further analysed using a Technology Maturity Index (TMI, 1\u20135) and regulatory signals (Food and Drug Administration (FDA) clearance, Conformit\u00e9 Europ\u00e9enne (CE) marking, clinical evidence). Kaplan\u2013Meier analysis modelled time to first grant, and translational attrition was mapped across the translation process.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 201 endodontic patent families, 112 (55.7%) were granted in at least one major market. Median time until the first patent was granted was 1652\u2009days (Interquartile Range (IQR) 1290\u20132043). Instrumentation dominated (80.1%), and energy\u2010based devices showed a numerically higher grant rate (66.7%), although this difference was not statistically significant. Twenty families (10.0%) carried identifiable regulatory or commercial signals; 16 (80.0%) reached near\u2010commercial maturity (TMI \u2265\u20094) and 15 achieved TMI\u2009=\u20095, representing 7.5% of the original cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Endodontic technology translation is prolonged and highly selective, showing progressive narrowing from filing to commercial realization, with only 7.5% (15\/201) of the families reaching confirmed full market availability. These findings provide a descriptive framework for interpreting emerging technologies and highlight the need to consider both time and attrition when evaluating innovation in endodontics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70259","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:18:48Z","timestamp":1787134728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Patent to Practice? A Retrospective Cohort Analysis of Translational Attrition in Endodontic Innovation"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7493-5026","authenticated-orcid":false,"given":"H.","family":"Better","sequence":"first","affiliation":[{"name":"Maccabi\u2010Dent Medical and Quality Assurance Department  Tel Aviv Israel"},{"name":"Maccabi\u2010Dent Research Department  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1875-7402","authenticated-orcid":false,"given":"T.","family":"Asbi","sequence":"additional","affiliation":[{"name":"Maccabi\u2010Dent Research Department  Tel Aviv Israel"},{"name":"Department of Periodontology Rambam Health Care Campus  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9176-4978","authenticated-orcid":false,"given":"G.","family":"Chaushu","sequence":"additional","affiliation":[{"name":"Maccabi\u2010Dent Research Department  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7406-2179","authenticated-orcid":false,"given":"K.","family":"Better","sequence":"additional","affiliation":[{"name":"Department of Information and Computing Sciences Utrecht University  Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7657-0938","authenticated-orcid":false,"given":"J.","family":"Moshonov","sequence":"additional","affiliation":[{"name":"Maccabi\u2010Dent Research Department  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-0157","authenticated-orcid":false,"given":"S.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Dental Trauma Rambam Health Care Campus  Haifa Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine Technion\u2013Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9238-7940","authenticated-orcid":false,"given":"D.","family":"Haim","sequence":"additional","affiliation":[{"name":"Maccabi\u2010Dent Research Department  Tel Aviv Israel"},{"name":"Department of Health Management Faculty of Health Sciences, Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.5395\/rde.2022.47.e11","article-title":"Outcomes of the GentleWave System on Root Canal Treatment: A Narrative Review","volume":"47","author":"Coaguila\u2010Llerena H.","year":"2022","journal-title":"Restorative Dentistry & Endodontics"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.i3323","article-title":"Comparison of Rates of Safety Issues and Reporting of Trial Outcomes for Medical Devices Approved in the European Union and United States: Cohort Study","volume":"353","author":"Hwang T. 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