{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T10:15:40Z","timestamp":1788257740074,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Root canal treatment (RCT) is recommended for compromised teeth in patients with radiation therapy (RT) for head and neck cancer (HNC), to minimise extraction\u2010related osteoradionecrosis (ORN). However, literature on endodontic outcomes in irradiated patients is scarce. This retrospective clinical study aimed to investigate healing outcome, survival, and their associated prognostic factors in teeth that received non\u2010surgical RCT in irradiated HNC patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent RT for HNC and subsequently received RCT between 2011 and 2022 were identified from electronic clinical records. Healing outcome and tooth survival were assessed from clinical and radiographic data. Radiation dose to each tooth and its periapical region was quantified by delineating these structures on RT planning CT scans. Healing was classified as healed\/healing or diseased using predefined clinical and radiographic criteria. Associations between prognostic factors and healing or survival were analysed using mixed\u2010effects logistic and Cox regression models, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 170 teeth in 82 patients were included. Among teeth reviewed at 1\u20134\u2009years, 82.4% (108\/131) were classified as healed\/healing. Estimated survival was 85.8% (95% CI: 78.1%\u201394.3%) at 7\u2009years, declining to 55.7% (95% CI: 37.4%\u201355.7%) at a maximum follow\u2010up of 132\u2009months. Pre\u2010operative mobility significantly predicted both poorer healing (OR\u2009=\u200910.0; 95% CI: 1.47\u201368.5) and increased extraction risk (HR\u2009=\u200944.5; 95% CI: 6.38\u2013310). Increasing age at RCT initiation was also associated with tooth loss (HR\u2009=\u20091.09 per year; 95% CI: 1.01\u20131.17). Radiation dose to the tooth or periapical region was not associated with healing or survival, and no cases of ORN were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Healing and survival of endodontically treated teeth in irradiated HNC patients were favourable. Pre\u2010operative tooth mobility was associated with poorer healing and increased risk of tooth loss and should be considered during pre\u2010radiotherapy dental assessment. In contrast, no statistically significant association was detected between radiation dose to the tooth or periapical region and healing or survival outcomes in this cohort. These findings support endodontic treatment as a means of preserving compromised teeth in irradiated jaws and reducing the risk of extraction\u2010related ORN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70260","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T09:39:40Z","timestamp":1788255580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tooth\u2010Level Radiation Dosimetry and Outcomes of Root Canal Treatment in Irradiated Patients: A Retrospective Cohort Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-6479-9694","authenticated-orcid":false,"given":"Sandra Ming Shu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry National Dental Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5191-3780","authenticated-orcid":false,"given":"Siwen","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry National Dental Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3191-5046","authenticated-orcid":false,"given":"Yu Fan","family":"Sim","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0688-3206","authenticated-orcid":false,"given":"Boon Fei","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3677-8669","authenticated-orcid":false,"given":"Yoke Lim","family":"Soong","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2546-9652","authenticated-orcid":false,"given":"Victoria Soo Hoon","family":"Yu","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-0578","authenticated-orcid":false,"given":"Jeen\u2010Nee","family":"Lui","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry National Dental Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"issue":"3","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/j.seminoncol.2019.07.002","article-title":"Modern Radiotherapy for Head and Neck Cancer","volume":"46","author":"Alterio D.","year":"2019","journal-title":"Seminars in Oncology"},{"issue":"5","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.oooo.2017.08.004","article-title":"Osteoradionecrosis: A Review of Pathophysiology, Prevention and Pharmacologic Management Using Pentoxifylline, \u03b1\u2010Tocopherol, and Clodronate","volume":"124","author":"Antonio Rivero J.","year":"2017","journal-title":"Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology"},{"issue":"3","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.7150\/ijms.3635","article-title":"Cancer and Radiation Therapy: Current Advances and Future Directions","volume":"9","author":"Baskar R.","year":"2012","journal-title":"International Journal of Medical Sciences"},{"issue":"1","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/adj.12134","article-title":"Dental Management of Patients Irradiated for Head and Neck Cancer","volume":"59","author":"Beech N.","year":"2014","journal-title":"Australian Dental Journal"},{"issue":"1","key":"e_1_2_11_6_1","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.ijrobp.2009.09.040","article-title":"Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): An Introduction to the Scientific Issues","volume":"76","author":"Bentzen S. 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