{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:55:01Z","timestamp":1790841301526,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int Endodontic J"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the clinical and radiographic outcomes of partial pulpotomy performed with mineral trioxide aggregate (White MTA Angelus) or a premixed calcium silicate\u2010based putty cement (NeoPutty) in mature mandibular molars with deep carious lesions and to explore factors associated with treatment outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      In this randomized clinical trial, 139 mature permanent mandibular molars in adult patients (median age 36\u2009years), presenting with deep carious lesions located within 0\u20131.5\u2009mm from the pulp on radiographic examination and diagnosed with initial, mild, moderate or severe pulpitis according to the Wolters classification, underwent partial pulpotomy using White MTA Angelus (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200964) or NeoPutty (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200975). Clinical and radiographic outcomes were assessed after 24\u2009months using predefined success criteria. Multivariable analyses were performed to explore factors associated with treatment outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All 139 treated teeth completed the 24\u2010month follow\u2010up (100% recall rate). Clinical and radiographic success rates were 90.6% for White MTA Angelus and 92.0% for NeoPutty, with no statistically significant difference between groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.774). The overall success rate was 91.4%. Haemostasis time was significantly associated with treatment outcome (odds ratio\u2009=\u20090.623; 95% confidence interval: 0.429\u20130.905;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013), whereas preoperative pulpal diagnosis according to the Wolters classification was not significantly associated with treatment outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Partial pulpotomy achieved high 24\u2010month clinical and radiographic success with both White MTA Angelus and NeoPutty. Within the limitations of this study, haemostasis time, but not preoperative pulpal diagnosis according to the Wolters classification, was significantly associated with treatment outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      This study was registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      (NCT06881615)\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iej.70274","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:26:16Z","timestamp":1789716376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two\u2010Year Outcome of Partial Pulpotomy Using Mineral Trioxide Aggregate or a Premixed Calcium Silicate Cement: A Randomized Clinical Trial"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7857-6507","authenticated-orcid":false,"given":"Alberto","family":"Serrano","sequence":"first","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Biomedical and Health Sciences Universidad Europea de Madrid  Madrid Spain"},{"name":"Postgraduate Program in Endodontics Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6445-8243","authenticated-orcid":false,"given":"Emmanuel Jo\u00e3o","family":"Nogueira Leal Silva","sequence":"additional","affiliation":[{"name":"Department of Endodontics Fluminense Federal University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8690-2379","authenticated-orcid":false,"given":"Henry F.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Division of Restorative Dentistry &amp; Periodontology Dublin Dental University Hospital, Trinity College Dublin  Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0500-8936","authenticated-orcid":false,"given":"Antonio Jes\u00fas Conde","family":"Villar","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Biomedical and Health Sciences Universidad Europea de Madrid  Madrid Spain"},{"name":"Postgraduate Program in Endodontics Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4228-3729","authenticated-orcid":false,"given":"Gaizka","family":"Loro\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Biomedical and Health Sciences Universidad Europea de Madrid  Madrid Spain"},{"name":"Postgraduate Program in Endodontics Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7977-0662","authenticated-orcid":false,"given":"Roberto","family":"Est\u00e9vez","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Biomedical and Health Sciences Universidad Europea de Madrid  Madrid Spain"},{"name":"Postgraduate Program in Endodontics Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6610-8183","authenticated-orcid":false,"given":"Claudia","family":"Brizuela","sequence":"additional","affiliation":[{"name":"Centro Activa Biosilicate Technology de Investigaci\u00f3n en Biolog\u00eda y Regeneraci\u00f3n Oral CIBRO, Faculty of Dentistry Universidad de los Andes  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-8059","authenticated-orcid":false,"given":"Ruth","family":"P\u00e9rez Alfayate","sequence":"additional","affiliation":[{"name":"Department of Clinical Dentistry, Faculty of Biomedical and Health Sciences Universidad Europea de Madrid  Madrid Spain"},{"name":"Postgraduate Program in Endodontics Universidad Europea de Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12611"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"240","article-title":"NeoPUTTY Versus NeoMTA 2 as a Pulpotomy Medicament for Primary Molars: A Randomized Clinical Trial","volume":"45","author":"Alqahtani A. 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