{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T19:34:49Z","timestamp":1791056089648,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T00:00:00Z","timestamp":1361232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We propose that canine visceral leishmaniasis (<jats:styled-content style=\"fixed-case\">CVL<\/jats:styled-content>) is a systemic fibrotic disease, as evidenced by the wide distribution of fibrosis that we have found in the dogs suffering from chronic condition. The inflammatory cells apparently direct fibrosis formation. Twenty\u2010four cases (symptomatic dogs) were identified from a total of one hundred and five cases that had been naturally infected with <jats:italic><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>eishmania chagasi<\/jats:italic> and had been documented during an epidemiological survey of <jats:styled-content style=\"fixed-case\">CVL<\/jats:styled-content> carried out by the metropolitan area of the municipality of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>elo <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>orizonte, <jats:styled-content style=\"fixed-case\">MG<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> B<\/jats:styled-content>razil. The histological criterion was intralobular liver fibrosis, as has been described previously in dogs with visceral leishmaniasis. In addition to the findings in the liver, here we describe and quantify conspicuous and systemic deposition of collagen in other organs, including spleen, cervical lymph nodes, lung and kidney of all the infected symptomatic dogs. Thus we report that there is a systematic fibrotic picture in these animals, where inflammatory cells appear to direct fibrosis in all organs that have been studied. Therefore we propose that <jats:styled-content style=\"fixed-case\">CVL<\/jats:styled-content> is a systemic fibrotic disease.<\/jats:p>","DOI":"10.1111\/iep.12010","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T16:24:39Z","timestamp":1361291079000},"page":"133-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Canine visceral leishmaniasis as a systemic fibrotic disease"],"prefix":"10.1111","volume":"94","author":[{"given":"Lucelia C.","family":"Silva","sequence":"first","affiliation":[{"name":"Departamento de Patologia Geral Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo S.","family":"Castro","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria M.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilene S. M.","family":"Michalick","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Washington L.","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Departamento de Anatomia Patol\u00f3gica Faculdade de Medicina Universidade Federal de Minas Gerais Belo Horizonte MG Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner L.","family":"Tafuri","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2007.76.53"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20267"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(04)57001-X"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588001700110"},{"key":"e_1_2_7_6_1","first-page":"371","article-title":"[Interstitial pneumonitis in kala\u2010azar]","volume":"55","author":"Andrade Z.A.","year":"1959","journal-title":"Hospital"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1983.tb01886.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.2.775"},{"key":"e_1_2_7_9_1","volume-title":"Princ\u00edpios de Morfometria Digital: KS300 Para Iniciantes, Vol. 1","author":"Caliari M.V.","year":"1997"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.141.21.539"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.40-6-677"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.45-5-613"},{"key":"e_1_2_7_13_1","unstructured":"1956 D.A. De Paola A Pun\u00e7\u00e3o\u2010Bi\u00f3psia do F\u00edgado. Valor da Pesquisa Histoqu\u00edmica 8 13"},{"key":"e_1_2_7_14_1","first-page":"75","article-title":"Leishmaniose visceral urbana (no c\u00e3o e no homem) em Sobral, Cear\u00e1","volume":"47","author":"Deane L.M.","year":"1955","journal-title":"O Hosp."},{"key":"e_1_2_7_15_1","first-page":"89","article-title":"[Visceral leishmaniasis in Central and South America]","volume":"29","author":"Deane L.M.","year":"1964","journal-title":"Arq. Hig. Saude Publica"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(84)90242-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651986000600009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90712-8"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800414"},{"key":"e_1_2_7_20_1","first-page":"877","article-title":"Histopathological and parasitological investigations of ear healthy skin of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi","volume":"25","author":"Figueiredo M.M.","year":"2010","journal-title":"Histol. Histopathol."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652003000300007"},{"key":"e_1_2_7_22_1","first-page":"323","article-title":"Structural and ultrastructural hepatic changes in experimental canine leishmaniasis","volume":"3","author":"Gonzalez J.L.","year":"1988","journal-title":"Histol. Histopathol."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3083.2001.00885.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1086\/515289"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30542"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01002772"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100113"},{"key":"e_1_2_7_28_1","first-page":"1119","article-title":"Immunoblot analysis of the humoral immune response to Leishmania donovani polypeptides in cases of human visceral leishmaniasis: its usefulness in prognosis","volume":"9","author":"Kumar P.","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"e_1_2_7_29_1","first-page":"188","article-title":"Canine leishmaniasis in Canada","volume":"13","author":"Lennox W.J.","year":"1972","journal-title":"Can. Vet. J."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2004.04.007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2007.02.012"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-009-0169-0"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(93)90195-S"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(00)01637-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.79.198"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2009.00681.x"},{"key":"e_1_2_7_37_1","first-page":"402","article-title":"Les cirrhoses hepatiques due au Kalazar","volume":"89","author":"Nattan\u2010Larrier L.","year":"1918","journal-title":"Bull. l'Acad Med."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(92)90025-5"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761993000200011"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1751-0147-53-67"},{"key":"e_1_2_7_41_1","first-page":"1291","article-title":"[Contribution to the Knowledge of the Pathological Anatomy of Visceral Leishmaniasis, with Special Reference to the Pulmonary and Cardiac Lesions]","volume":"65","author":"Raso P.","year":"1964","journal-title":"O Hosp."},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1908.11684879"},{"key":"e_1_2_7_43_1","first-page":"1493","article-title":"Canine and feline lymph nodes. Part II. Diagnosis, evaluation and lymphadenopathy","volume":"15","author":"Rogers K.S.","year":"1993","journal-title":"Compendium"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2004.70.618"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1988.9694140"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(03)00063-X"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9919"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700811"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0307191"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651989000300002"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651996000200001"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(00)00436-2"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2004.05.009"},{"key":"e_1_2_7_54_1","first-page":"1","article-title":"Visceral leishmaniasis in a dog: clinical, hematological and pathological observations","volume":"41","author":"Tryphonas L.","year":"1977","journal-title":"Can. J. Comp. Med."},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2008.11.009"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001760303"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.12.001"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1412"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31487"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2277"}],"container-title":["International Journal of Experimental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiep.12010","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T07:12:46Z","timestamp":1700637166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iep.12010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,19]]},"references-count":59,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/iep.12010"],"URL":"https:\/\/doi.org\/10.1111\/iep.12010","archive":["Portico"],"relation":{},"ISSN":["0959-9673","1365-2613"],"issn-type":[{"value":"0959-9673","type":"print"},{"value":"1365-2613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,19]]},"assertion":[{"value":"2012-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}