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To determine whether the common marmoset (<jats:italic><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>allithrix jacchus<\/jats:italic>) would be an appropriate model to assess therapies against Marburg haemorrhagic fever, initial susceptibility, lethality and pathogenesis studies were performed. Low doses of virus, between 4 and 28 <jats:styled-content style=\"fixed-case\">TCID<jats:sub>50<\/jats:sub><\/jats:styled-content>, were sufficient to cause a lethal, reproducible infection. Animals became febrile between days 5 and 6, maintaining a high fever before succumbing to disease between 8 and 11\u00a0days postchallenge. Typical signs of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arburg virus infection were observed including haemorrhaging and a transient rash. In pathogenesis studies, virus was isolated from the animals\u2019 lungs from day 3 postchallenge and from the liver, spleen and blood from day 5 postchallenge. Early signs of histopathology were apparent in the kidney and liver from day 3. The most striking features were observed in animals exhibiting severe clinical signs, which included high viral titres in all organs, with the highest levels in the blood, increased levels in liver function enzymes and blood clotting times, decreased levels in platelets, multifocal moderate\u2010to\u2010severe hepatitis and perivascular oedema.<\/jats:p>","DOI":"10.1111\/iep.12018","type":"journal-article","created":{"date-parts":[[2013,2,27]],"date-time":"2013-02-27T08:08:52Z","timestamp":1361952532000},"page":"156-168","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Experimental respiratory <scp>M<\/scp>arburg virus haemorrhagic fever infection in the common marmoset (<i><scp>C<\/scp>allithrix jacchus<\/i>)"],"prefix":"10.1111","volume":"94","author":[{"given":"Sophie J.","family":"Smither","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Dstl, Porton Down Salisbury Wiltshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Dstl, Porton Down Salisbury Wiltshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Eastaugh","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Dstl, Porton Down Salisbury Wiltshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas R.","family":"Laws","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Dstl, Porton Down Salisbury Wiltshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Dstl, Porton Down Salisbury Wiltshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Dstl, Porton Down Salisbury Wiltshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Salguero","sequence":"additional","affiliation":[{"name":"Department of Pathology, Animal Health Veterinary Laboratories Agency Veterinary Laboratories Agency \u2013 Weybridge Addlestone Surrey UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Lever","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Dstl, Porton Down Salisbury Wiltshire UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00674-08"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810378597"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.20859"},{"key":"e_1_2_6_5_1","volume-title":"Theory and Practice of histological techniques","author":"Bancroft J.D.","year":"2008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711250303"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711470308"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0076"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.01.152"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.000471"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.18.2391"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(78)90058-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-6-1365"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00200-0"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/515386"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcpa.2001.0503"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02876-06"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.08.022"},{"key":"e_1_2_6_19_1","unstructured":"Center for Disease Control List of Bioterrorism Agents(2010).CDC website. 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