{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:55:50Z","timestamp":1789041350397,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T00:00:00Z","timestamp":1397692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Program of the Walloon Region","award":["Neoangio Nu 616476"],"award-info":[{"award-number":["Neoangio Nu 616476"]}]},{"name":"Belgian National Funds for Scientific Research (FNRS)"},{"name":"Averroes Program of the European Commission"},{"name":"F.R.S-FNRS"},{"name":"Neoangio"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Undifferentiated cell Transcription Factor 1 (<jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1) is a chromatin\u2010bound protein involved in stem cell differentiation. It was initially reported to be restricted to stem cells or germinal tissues. However, recent work suggests that <jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1 is also expressed in somatic cells and that its expression may increase during carcinogenesis. To further clarify the expression profile of <jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1, we evaluated <jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1 expression levels immunohistochemically in eight normal human epithelia (from breast, prostate, endometrium, bladder, colon, oesophagus, lung and kidney) and their corresponding tumours as well as in several epithelial cell lines. We showed <jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1 staining in normal and tumour epithelial tissues, but with varying intensities according to the tissue location. <jats:italic>In vitro<\/jats:italic> analyses also revealed that <jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1 is expressed in somatic epithelial cell lines even in the absence of Oct4A and Sox2, its two main known regulators. The comparison of <jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1 levels in normal and tumoral tissues revealed significant overexpression in endometrial and prostatic adenocarcinomas, whereas lower intensity of the staining was observed in renal and colic tumours, suggesting a potential tissue\u2010specific function of <jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1. Altogether, these results highlight a potential dual role for <jats:styled-content style=\"fixed-case\">UTF<\/jats:styled-content>1, acting either as an oncogene or as a tumour suppressor depending on the tissue. These findings also question its role as a specific marker for stem cells.<\/jats:p>","DOI":"10.1111\/iep.12077","type":"journal-article","created":{"date-parts":[[2014,4,17]],"date-time":"2014-04-17T10:28:54Z","timestamp":1397730534000},"page":"251-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Expression profile of undifferentiated cell transcription factor 1 in normal and cancerous human epithelia"],"prefix":"10.1111","volume":"95","author":[{"given":"Mustapha","family":"Mouallif","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Pathology GIGA\u2010Cancer University of Li\u00e8ge Li\u00e8ge Belgium"},{"name":"Laboratory of Virology and Hygiene &amp; Microbiology University Hassan II\u2010Mohammedia Mohammedia Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelin","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Zeddou","sequence":"additional","affiliation":[{"name":"Laboratory of Rheumatology University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My Mustapha","family":"Ennaji","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Hygiene &amp; Microbiology University Hassan II\u2010Mohammedia Mohammedia Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Delvenne","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathology GIGA\u2010Cancer University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Guenin","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Pathology GIGA\u2010Cancer University of Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200702058"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-07-0536"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20942"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2009.00068"},{"key":"e_1_2_8_6_1","first-page":"6488","article-title":"Increase of GKLF messenger RNA and protein expression during progression of breast cancer","volume":"60","author":"Foster K.W.","year":"2000","journal-title":"Cancer Res."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0673"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2010.01.023"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042704"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.09.023"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-2047-y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2009.02.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den010"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaq008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.11.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.13.8890"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.8.5453"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.12.5084-5094.2005"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.7.2019"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604193"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016617"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-10-0677"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2613.2011.00769.x"},{"key":"e_1_2_8_24_1","first-page":"2111","article-title":"CD133 expression is not restricted to stem cells, and both CD133+\u00a0 and CD133\u2010 metastatic colon cancer cells initiate tumors","volume":"118","author":"Shmelkov S.V.","year":"2008","journal-title":"J. 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