{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:36:36Z","timestamp":1761489396999,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T00:00:00Z","timestamp":1404086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006181","name":"Fapesb","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004809","name":"FINEP","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Infection by <jats:italic>Trypanosoma cruzi<\/jats:italic>, the aetiological agent of Chagas disease, causes an intense inflammatory reaction in several tissues, including the myocardium. We have previously shown that transplantation of bone marrow cells (<jats:styled-content style=\"fixed-case\">BMC<\/jats:styled-content>) ameliorates the myocarditis in a mouse model of chronic Chagas disease. We investigated the participation of <jats:styled-content style=\"fixed-case\">BMC<\/jats:styled-content> in lesion repair in the heart and skeletal muscle, caused by <jats:italic>T.\u00a0cruzi<\/jats:italic> infection in mice. Infection with a myotropic <jats:italic>T.\u00a0cruzi<\/jats:italic> strain induced an increase in the percentage of stem cells and monocytes in the peripheral blood, as well as in gene expression of chemokines <jats:styled-content style=\"fixed-case\">SDF<\/jats:styled-content>\u20101, <jats:styled-content style=\"fixed-case\">MCP<\/jats:styled-content>1, 2, and 3 in the heart and skeletal muscle. To investigate the fate of <jats:styled-content style=\"fixed-case\">BMC<\/jats:styled-content> within the damaged tissue, chimeric mice were generated by syngeneic transplantation of green fluorescent protein (<jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content><jats:sup>+<\/jats:sup>) <jats:styled-content style=\"fixed-case\">BMC<\/jats:styled-content> into lethally irradiated mice and infected with <jats:italic>Trypanosoma cruzi<\/jats:italic>. Migration of <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content><jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">BMC<\/jats:styled-content> to the heart and skeletal muscle was observed during and after the acute phase of infection. <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content><jats:sup>+<\/jats:sup> cardiomyocytes and endothelial cells were present in heart sections of chimeric chagasic mice. <jats:styled-content style=\"fixed-case\">GFP<\/jats:styled-content><jats:sup>+<\/jats:sup> myofibres were observed in the skeletal muscle of chimeric mice at different time points following infection. In conclusion, <jats:styled-content style=\"fixed-case\">BMC<\/jats:styled-content> migrate and contribute to the formation of new resident cells in the heart and skeletal muscle, which can be detected both during the acute and the chronic phase of infection. These findings reinforce the role of <jats:styled-content style=\"fixed-case\">BMC<\/jats:styled-content> in tissue regeneration.<\/jats:p>","DOI":"10.1111\/iep.12089","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:47:16Z","timestamp":1404175636000},"page":"321-329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Bone marrow cells migrate to the heart and skeletal muscle and participate in tissue repair after <i><scp>T<\/scp>rypanosoma cruzi<\/i> infection in mice"],"prefix":"10.1111","volume":"95","author":[{"given":"Bruno S. d. F.","family":"Souza","sequence":"first","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz Salvador Brazil"},{"name":"Centro de Biotecnologia e Terapia Celular Hospital S\u00e3o Rafael Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carine M.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz Salvador Brazil"},{"name":"Centro de Biotecnologia e Terapia Celular Hospital S\u00e3o Rafael Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo S. d.","family":"Lima","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla M.","family":"Kaneto","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia e Terapia Celular Hospital S\u00e3o Rafael Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana F.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz Salvador Brazil"},{"name":"Centro de Biotecnologia e Terapia Celular Hospital S\u00e3o Rafael Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisalva T.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo R.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz Salvador Brazil"},{"name":"Centro de Biotecnologia e Terapia Celular Hospital S\u00e3o Rafael Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena B. P.","family":"Soares","sequence":"additional","affiliation":[{"name":"Centro de Pesquisas Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz Salvador Brazil"},{"name":"Centro de Biotecnologia e Terapia Celular Hospital S\u00e3o Rafael Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(03)00281-5"},{"key":"e_1_2_6_3_1","first-page":"214","article-title":"Mechanisms of myocardial damage in Trypanosoma cruzi infection","volume":"99","author":"Andrade Z.A.","year":"1983","journal-title":"Ciba Found. Symp."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2002)088[0919:CMHAPC]2.0.CO;2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070075"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.19-3-180"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm963"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp220"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm959"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762009000900006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000061910.39145.F0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1110364"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63165-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1964.13.272"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-2498(03)00035-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.05.008"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/526793"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.049"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60472-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2005.14.676"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0026"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)01078-4"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000014822.62629.EB"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-178939"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7580.2009.01138.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60061-X"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1203-1461"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-012-9383-6"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2006.09.011"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11682"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63134-3"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.2217\/17460751.2.3.257"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/653481"},{"key":"e_1_2_6_34_1","first-page":"201","article-title":"Regeneration of heart muscle tissue: quantification of chimeric cardiomyocytes and endothelial cells following transplantation","volume":"19","author":"Thiele J.","year":"2004","journal-title":"Histol. Histopathol."},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.418"}],"container-title":["International Journal of Experimental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiep.12089","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:36:13Z","timestamp":1696289773000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iep.12089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,30]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/iep.12089"],"URL":"https:\/\/doi.org\/10.1111\/iep.12089","archive":["Portico"],"relation":{},"ISSN":["0959-9673","1365-2613"],"issn-type":[{"type":"print","value":"0959-9673"},{"type":"electronic","value":"1365-2613"}],"subject":[],"published":{"date-parts":[[2014,6,30]]},"assertion":[{"value":"2013-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-06-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}