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One hundred and thirty\u2010five Wistar rats were divided into three main groups: Control (Na\u00efve), Sham and <jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content>. The animals received pretreatment one hour before surgery. The Na\u00efve group did not undergo any procedure or pretreatment. The Sham group only had the caecum exposed and was pretreated with saline. The <jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> group was divided into three pretreatments: metyrapone (<jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> met 50\u00a0mg\/kg i.p.), dexamethasone (<jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> dex 0.5\u00a0mg\/kg i.p.) or saline (<jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> sal equivalent volume of 0.9% NaCl). Analyses were performed after 6 and 24\u00a0h of sepsis. Previous administration of met significantly increased inflammatory cells, as well as myeloperoxidase (<jats:styled-content style=\"fixed-case\">MPO<\/jats:styled-content>) activity in the lung tissue and alveolar collapsed area, with consequent impairment of respiratory mechanics being observed compared to Sham and Na\u00efve; <jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> sal exhibited similar results to those of met. The met reduced corticosterone (<jats:styled-content style=\"fixed-case\">CCT<\/jats:styled-content>) levels and dramatically increased hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) levels in the lung tissue compared to <jats:styled-content style=\"fixed-case\">CLP<\/jats:styled-content> sal. Our results suggest that previous administration of met may have contributed to increased pulmonary oxidative stress and increased mortality by mechanisms dependent of endogenous <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iep.12113","type":"journal-article","created":{"date-parts":[[2015,2,9]],"date-time":"2015-02-09T09:26:56Z","timestamp":1423474016000},"page":"133-139","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inhibition of endogenous glucocorticoid synthesis aggravates lung injury triggered by septic shock in rats"],"prefix":"10.1111","volume":"96","author":[{"given":"Erika K.","family":"Incerpi","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences UNIFAL\u2010MG Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pharmacology USP S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elis\u00e2ngela M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis UNIFAL\u2010MG Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roseli","family":"Soncini","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences UNIFAL\u2010MG Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.2.2003122"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-3005"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.8.1038"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.11.030"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-005-9056-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0883-9441(94)90033-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1001903221046"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802006000200008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-31802007000400009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.3.908"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.1.168"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.2.7842182"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.4_Pt_1.878"},{"key":"e_1_2_8_15_1","first-page":"299","article-title":"Pharmacological modulation of HPA axis in depression \u2010 new avenues for potential therapeutic benefits","volume":"25","author":"Maric N.P.","year":"2013","journal-title":"Psychiatr. 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