{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:57Z","timestamp":1787014317674,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Dr. Falk Pharma GmbH"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Trichuris suis ova<\/jats:italic>\n                    (\n                    <jats:styled-content style=\"fixed-case\">TSO<\/jats:styled-content>\n                    ) have shown promising results in the treatment of inflammatory bowel disease (\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    ) but the mechanisms which underlies this therapeutic effect cannot be studied in mice and rats as\n                    <jats:italic>T.\u00a0suis<\/jats:italic>\n                    fails to colonize the rodent intestine, whilst hatching in humans and rabbits. As a suitable rabbit\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    model is currently not available, we developed a rabbit colitis model by administration of dextran sodium sulphate (\n                    <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                    ). White Himalayan rabbits (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a012) received 0.1%\n                    <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                    in the daily water supply for five days. Clinical symptoms were monitored daily, and rabbits were sacrificed at different time points. A genomewide expression analysis was performed with\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    isolated from caecal lamina propria mononuclear cells (\n                    <jats:styled-content style=\"fixed-case\">LPMC<\/jats:styled-content>\n                    ) and intestinal epithelial cells (\n                    <jats:styled-content style=\"fixed-case\">IEC<\/jats:styled-content>\n                    ). The disease activity index of\n                    <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                    rabbits increased up to 2.1\u00a0\u00b1\u00a00.4 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06) at day 10 (controls &lt;0.5).\n                    <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                    induced a caecum\u2010localized pathology with crypt architectural distortion, stunted villous surface and inflammatory infiltrate in the lamina propria. The histopathology score reached a peak of 14.2\u00a0\u00b1\u00a04.9 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a04) at day 10 (controls 7.7\u00a0\u00b1\u00a00.9,\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a05). Expression profiling revealed an enrichment of\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    \u2010related genes in both\n                    <jats:styled-content style=\"fixed-case\">LPMC<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">IEC<\/jats:styled-content>\n                    . Innate inflammatory response, Th17 signalling and chemotaxis were among the pathways affected significantly. We describe a reproducible and reliable rabbit model of\n                    <jats:styled-content style=\"fixed-case\">DSS<\/jats:styled-content>\n                    colitis. Localization of the inflammation in the caecum and its similarities to\n                    <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>\n                    make this model particularly suitable to study\n                    <jats:styled-content style=\"fixed-case\">TSO<\/jats:styled-content>\n                    therapy\n                    <jats:italic>in vivo<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/iep.12117","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T02:25:50Z","timestamp":1424917550000},"page":"151-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Oral administration of dextran sodium sulphate induces a caecum\u2010localized colitis in rabbits"],"prefix":"10.1111","volume":"96","author":[{"given":"Irina","family":"Leonardi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flora","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Central Biological Laboratory University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstin","family":"Atrott","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Cee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Tewes","sequence":"additional","affiliation":[{"name":"Research and Development Dr. Falk Pharma GmbH Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Greinwald","sequence":"additional","affiliation":[{"name":"Research and Development Dr. Falk Pharma GmbH Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Rogler","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0125-3072","authenticated-orcid":false,"given":"Isabelle","family":"Frey\u2010Wagner","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20753"},{"key":"e_1_2_6_3_1","first-page":"215","article-title":"The characterization of a rabbit model of inflammatory bowel disease","volume":"76","author":"Anthony D.","year":"1995","journal-title":"Int. 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