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Reducing the expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A could attenuate inflammation in the lungs. However, whether <jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content> exerts its anti\u2010inflammatory effects by regulating the expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A has remained unclear. Here, we show that there is a remarkable increase of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A in\u00a0bronchoalveolar lavage fluid (<jats:styled-content style=\"fixed-case\">BALF<\/jats:styled-content>) and lung tissue of mice with acute lung injury (<jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content>). Moreover, lipopolysaccharides (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) stimulated elevated expression of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017A, which was evident by the enhanced levels of m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> and protein observed. Furthermore, we also found that <jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content> inhibited <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>\u2010mediated IL\u201017A expression in a time\u2010 and dose\u2010dependent manner in an <jats:italic>in\u00a0vitro<\/jats:italic> model of <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content> and that this process might be mediated via the phosphokinase A (<jats:styled-content style=\"fixed-case\">PKA<\/jats:styled-content>) and phosphokinase C (<jats:styled-content style=\"fixed-case\">PKC<\/jats:styled-content>) pathways. Taken together, our results demonstrated that <jats:styled-content style=\"fixed-case\">VIP<\/jats:styled-content> might be an effective protector during <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content> by suppressing IL\u201017A expression.<\/jats:p>","DOI":"10.1111\/iep.12130","type":"journal-article","created":{"date-parts":[[2015,5,5]],"date-time":"2015-05-05T09:25:23Z","timestamp":1430817923000},"page":"269-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Vasoactive intestinal peptide suppresses macrophage\u2010mediated inflammation by downregulating interleukin\u201017A expression via PKA\u2010 and PKC\u2010dependent pathways"],"prefix":"10.1111","volume":"96","author":[{"given":"Wen\u2010Zhuo","family":"Ran","sequence":"first","affiliation":[{"name":"Department of Physiology Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Medicine Central South University Changsha China"},{"name":"Department of Anesthesiology People's Hospital of Liuzhou City Liuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Ying","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cha\u2010Xiang","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Medicine Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042654"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182266779"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00059-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-011-1184-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.4049\/jimmunol.162.4.2358","article-title":"Vasoactive intestinal peptide and pituitary adenylate cyclase\u2010activating polypeptide inhibit endotoxin\u2010induced TNF\u2010alpha production by macrophages: in\u00a0vitro and in\u00a0vivo studies","volume":"162","author":"Delgado M.","year":"1999","journal-title":"J. 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