{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:50:18Z","timestamp":1790495418154,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,10,29]],"date-time":"2015-10-29T00:00:00Z","timestamp":1446076800000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chronic obstructive pulmonary disease is often associated with chronic comorbid conditions of cardiovascular disease, diabetes mellitus and hypertension. This study aimed to investigate the effects of the association of diabetes and pulmonary emphysema on cardiac structure and function in rats. Wistar rats were divided into control non\u2010diabetic instilled with saline (CS) or elastase (<jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content>), diabetic instilled with saline (<jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content>) or elastase (<jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content> treated with insulin (<jats:styled-content style=\"fixed-case\">DEI<\/jats:styled-content>) groups and echocardiographic measurements, morphometric analyses of the heart and lungs, and survival analysis conducted 50\u00a0days after instillation. Diabetes mellitus was induced [alloxan, 42\u00a0mg\/kg, intravenously (iv)] 10\u00a0days before the induction of emphysema (elastase, 0.25\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/100\u00a0g). Rats were treated with <jats:styled-content style=\"fixed-case\">NPH<\/jats:styled-content> insulin (4\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content> before elastase plus 2\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/day, 50\u00a0days). Both <jats:styled-content style=\"fixed-case\">CE<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content> exhibited similar increases in mean alveolar diameter, which are positively correlated with increases in right ventricular (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) wall thickness (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0022), cavity area (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001) and cardiomyocyte thickness (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001). Diabetic saline group demonstrated a reduction in left ventricular (<jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>) wall, interventricular (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) septum, cardiomyocyte thickness and an increase in cavity area, associated with a reduction in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content> fractional shortening (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05), and an increase in <jats:styled-content style=\"fixed-case\">LV<\/jats:styled-content>iv relaxation time (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Survival rate decreased from 80% in <jats:styled-content style=\"fixed-case\">DS<\/jats:styled-content> group to 40% in <jats:styled-content style=\"fixed-case\">DE<\/jats:styled-content> group. In conclusion, alloxan diabetes did not affect <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> hypertrophy secondary to chronic emphysema, even in the presence of insulin. Diabetes <jats:italic>per se<\/jats:italic> induced left ventricular dysfunction, which was less evident in the presence of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> hypertrophy. Survival rate was substantially reduced as a consequence, at least in part, of the coexistence of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> hypertrophy and diabetic cardiomyopathy.<\/jats:p>","DOI":"10.1111\/iep.12146","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T05:09:37Z","timestamp":1446181777000},"page":"350-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of the association of diabetes and pulmonary emphysema on cardiac structure and function in rats"],"prefix":"10.1111","volume":"96","author":[{"given":"Antonio","family":"Di Petta","sequence":"first","affiliation":[{"name":"Heart Institute (InCor) LIM\u201011 University of S\u00e3o Paulo Medical School S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Simas","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) LIM\u201011 University of S\u00e3o Paulo Medical School S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clebson L.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Heart Institute (InCor) LIM\u201011 University of S\u00e3o Paulo Medical School S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera L.","family":"Capelozzi","sequence":"additional","affiliation":[{"name":"Department of Pathology University of S\u00e3o Paulo Medical School S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera M. 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