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We aimed to investigate the effects of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> on the testes of adult albino rats, examine the recovery response and evaluate the efficacy of naringenin (<jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>) supplementation. Adult male albino rats were randomly assigned to five groups of six each: control, <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content> (50\u00a0mg\/kg), <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> (70\u00a0mg\/kg), recovery (after subsequent withdrawal of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> group. All treatments were given by oral gavage for 6\u00a0weeks and another 3\u00a0weeks for the recovery group. At the time of sacrifice, each testis was weighed. Biochemical analysis of epididymal sperm count and serum testosterone level was performed. Testes were processed for histological, ultrastructural and c\u2010Kit immunohistochemical study. <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> toxicity was evidenced by a highly significant decrease in testicular weight, epididymal sperm count and serum testosterone level compared to control. Furthermore, testicular structure abnormalities and reduced c\u2010Kit immunoreactions were observed. Stoppage of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> in the recovery group partially reversed <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content>\u2010induced changes. There was a mild decrease in testicular weight and biochemical parameters compared to control. The structure of seminiferous tubules was partially retained. <jats:styled-content style=\"fixed-case\">The NG<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> group showed an overall improvement in testicular weight and biochemical alterations which were confirmed by light and electron microscopic examination. In conclusion, <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> induced testicular toxicity, which was ameliorated by <jats:styled-content style=\"fixed-case\">NG<\/jats:styled-content> co\u2010administration. However, stoppage of <jats:styled-content style=\"fixed-case\">PM<\/jats:styled-content> exposure was associated with partial recovery.<\/jats:p>","DOI":"10.1111\/iep.12168","type":"journal-article","created":{"date-parts":[[2016,2,12]],"date-time":"2016-02-12T08:33:20Z","timestamp":1455266000000},"page":"37-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Efficacy of naringenin against permethrin\u2010induced testicular toxicity in rats"],"prefix":"10.1111","volume":"97","author":[{"given":"Heba El\u2010Sayed","family":"Mostafa","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine and Clinical Toxicology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia A.","family":"Abd El\u2010Baset","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-0100","authenticated-orcid":false,"given":"Asmaa A. 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