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It causes the highest morbidity and mortality amongst all forms of tuberculosis. Matrix metalloproteinase\u20109 levels increase and cause inflammatory destruction during progression of the disease. Although corticosteroids are usually given as an adjuvant therapy to overcome these complications, treatment outcome is contradictory. This study was designed to evaluate whether specific inhibition of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 can be beneficial in management of the disease. <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 levels were inhibited using <jats:styled-content style=\"fixed-case\">SB<\/jats:styled-content>\u20103<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> or dexamethasone along with conventional drugs for treatment of tuberculous meningitis. Both <jats:styled-content style=\"fixed-case\">SB<\/jats:styled-content>\u20103<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> and dexamethasone decreased the elevated levels of <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109 in sera and tissues of the infected mice. However, dexamethasone administration had an inhibitory effect on bacillary clearance, while <jats:styled-content style=\"fixed-case\">SB<\/jats:styled-content>\u20103<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> potentiated the bacillary clearance, suggesting that <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20109, if specifically inhibited, can be beneficial in the management of <jats:styled-content style=\"fixed-case\">TBM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iep.12191","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T04:05:24Z","timestamp":1467864324000},"page":"230-237","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Adjunctive role of <scp>MMP<\/scp>\u20109 inhibition along with conventional anti\u2010tubercular drugs against experimental tuberculous meningitis"],"prefix":"10.1111","volume":"97","author":[{"given":"Shahnawaz","family":"Majeed","sequence":"first","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education &amp; Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishan D.","family":"Radotra","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education &amp; Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhna","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Postgraduate Institute of Medical Education &amp; Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.11.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/592447"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652409787581655"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/655224"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027900"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1100827"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.3030460322"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00015411"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(92)90192-N"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007277"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1563-05.2005"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076904"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-001-0333-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000173894.09553.13"},{"key":"e_1_2_7_16_1","first-page":"64","article-title":"Predictors of outcome in patients with tuberculous meningitis","volume":"6","author":"Hosoglu S.","year":"2002","journal-title":"Int. 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