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Wistar male rats, 21\u00a0days old, were allocated into the following: control (<jats:italic>n<\/jats:italic>\u00a0=\u00a017, received corn oil), MeHg (<jats:italic>n<\/jats:italic>\u00a0=\u00a017, received MeHg at 0.5\u00a0mg\/kg\/day), Aroclor (<jats:italic>n<\/jats:italic>\u00a0=\u00a017, received Aroclor at 1.0\u00a0mg\/kg\/day), low mix (<jats:italic>n<\/jats:italic>\u00a0=\u00a018, received MeHg at 0.05\u00a0mg\/kg\/day and Aroclor at 0.1\u00a0mg\/kg\/day), high mix (<jats:italic>n<\/jats:italic>\u00a0=\u00a018, received MeHg at 0.5\u00a0mg\/kg\/day and Aroclor at 1.0\u00a0mg\/kg\/day). Dosing continued from post natal day (PND) 23 to 53, by gavage. Euthanasia was performed on PND 53; or, after an interval of 62\u00a0days without exposure to chemicals, on PND 115. The degree of maturation of the seminiferous epithelium was delayed in chemical\u2010exposed groups and testicular interstitial oedema was observed at adulthood. The pattern of male gonad organization was changed in the Aroclor group on PND 53 and in all treated groups at adulthood. The animals from Aroclor, low mix and high mix groups showed a reduction in the number of Sertoli cells. Histological evidence of renal injury was observed in all chemical\u2010exposed groups in both ages. A probable target for MeHg and Aroclor in the reproductive system was Sertoli cells, in which possible dysfunctions could be linked to the other testicular alterations. Curiously, the main deleterious effects were late outcomes, along with the absence of synergistic interaction of MeHg and Aroclor in the parameters investigated. In conclusion, fish pollutants MeHg and Aroclor caused permanent structural damage in male gonads and kidneys after prepubertal exposure, without showing clear chemical interactions.<\/jats:p>","DOI":"10.1111\/iep.12200","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T05:49:01Z","timestamp":1480916941000},"page":"360-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fish pollutants MeHg and Aroclor cause permanent structural damage in male gonads and kidneys after prepubertal exposure"],"prefix":"10.1111","volume":"97","author":[{"given":"Mariana S.","family":"Garcia","sequence":"first","affiliation":[{"name":"Central de Laborat\u00f3rios de Ci\u00eancia e Tecnologia Ambiental Universidade Sagrado Cora\u00e7\u00e3o, USC Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce Helena J.","family":"Constantino","sequence":"additional","affiliation":[{"name":"Central de Laborat\u00f3rios de Ci\u00eancia e Tecnologia Ambiental Universidade Sagrado Cora\u00e7\u00e3o, USC Bauru S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana P. 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