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Inflammation and oxidative stress are closely linked with liver fibrosis, the major contributing factor to hepatic failure. Therefore, the aim of this study was to evaluate the impact of chronic exposure to\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    on the development of hepatic fibrosis in male rats and to determine the cross\u2010talk between the hepatic cytokine network, oxidative stress and apoptosis. For this purpose, 30 male Wistar albino rats were divided into three equal groups as follows: the first group was given no treatment (normal control group); the second group was given corn oil once daily by oral gavage for 8\u00a0weeks (vehicle control group); and the third group received\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    (50\u00a0mg\/kg body weight\/day, p.o.) for 8\u00a0weeks.\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    administration induced liver fibrosis as reflected in an increase in serum hepatic enzymes activities, hepatic hydroxyproline content and histopathological changes particularly increased collagen fibre deposition around the portal tract. In addition, there was inflammation (as reflected in increase in interleukin\u20101beta \u2018\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20101\u03b2\u2019, decrease in interleukin\u201010 \u2018\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201010\u2032 serum levels and increase in\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u20101\u03b2\/\n                    <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                    \u201010 ratio), oxidative stress (as reflected in increase in malondialdehyde (MDA) level, reduction in reduced glutathione (GSH) content and inhibition of catalase (CAT) activity) and apoptosis [as reflected in an increase in caspase\u20103 level and a decrease in numbers of B\u2010cell lymphoma 2 (\n                    <jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>\n                    2)\u2010immunopositive hepatocytes]. Interestingly,\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    had an upregulating effect on an extracellular matrix turnover gene [as reflected in matrix metalloproteinase\u20109 (\n                    <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                    \u20109)] and a downregulating effect on its inhibitor gene [as reflected in tissue inhibitor of matrix metalloproteinase\u20102 (\n                    <jats:styled-content style=\"fixed-case\">TIMP<\/jats:styled-content>\n                    \u20102)] expression. Thus, the mechanism by which\n                    <jats:styled-content style=\"fixed-case\">BPA<\/jats:styled-content>\n                    induced liver fibrosis seems to be related to stimulation of the inflammatory response, along with oxidative stress, the apoptotic pathway and activation of extracellular matrix turnover.\n                  <\/jats:p>","DOI":"10.1111\/iep.12207","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T07:36:47Z","timestamp":1481096207000},"page":"369-379","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A\u2010induced liver fibrosis in male rats"],"prefix":"10.1111","volume":"97","author":[{"given":"Sahar El\u2010Sayed","family":"Elswefy","sequence":"first","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Zagazig University Zagazig Sharkia Governorate Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Rizk","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Zagazig University Zagazig Sharkia Governorate Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebatallah Husseini","family":"Atteia","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Zagazig University Zagazig Sharkia Governorate Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa Samir","family":"Wahba","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Zagazig University Zagazig Sharkia Governorate Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab Abdallah","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Histology Faculty of Medicine for Girls Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2010.08.007"},{"key":"e_1_2_7_4_1","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler E.","year":"1963","journal-title":"J. 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