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Ductular reaction and the appearance of small hepatocytes are standard components of this response, which is thought to have both adverse (e.g. fibrosis, carcinogenesis) and beneficial (regeneration) consequences. This complex tissue reaction is regulated by orchestrated cytokine action. We have investigated the influence of the tyrosine kinase inhibitor imatinib on a regenerative process. Ductular reaction was induced in mice by the widely used choline\u2010deficient ethionine\u2010supplemented diet (<jats:styled-content style=\"fixed-case\">CDE<\/jats:styled-content>). Test animals were treated daily with imatinib. After 6\u00a0weeks of treatment, imatinib successfully reduced the extent of ductular reaction and fibrosis in the <jats:styled-content style=\"fixed-case\">CDE<\/jats:styled-content> model. Furthermore, the number of small hepatocytes increased, and these cells had high proliferative activity, were positive for hepatocyte nuclear factor 4 and expressed high levels of albumin and peroxisome proliferator\u2010activated receptor alpha. The overall functional zonality of the hepatic parenchyma (cytochrome P450 2E1 and glucose 6 phosphatase activity; endogenous biotin content) was maintained. The expression of platelet\u2010derived growth factor receptor beta, which is the major target of imatinib, was downregulated. The anti\u2010fibrotic activity of imatinib has already been reported in several experimental models. Additionally, in the <jats:styled-content style=\"fixed-case\">CDE<\/jats:styled-content> model imatinib was able to enhance regeneration and preserve the functional arrangement of hepatic lobules. These results suggest that imatinib might promote the recovery of the liver following parenchymal injury through the inhibition of platelet\u2010derived growth factor receptor beta.<\/jats:p>","DOI":"10.1111\/iep.12209","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T10:29:20Z","timestamp":1480933760000},"page":"389-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Imatinib accelerates progenitor cell\u2010mediated liver regeneration in choline\u2010deficient ethionine\u2010supplemented diet\u2010fed mice"],"prefix":"10.1111","volume":"97","author":[{"given":"Andr\u00e1s","family":"R\u00f3kusz","sequence":"first","affiliation":[{"name":"First Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edina","family":"Bugyik","sequence":"additional","affiliation":[{"name":"First Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessza","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"First Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armanda","family":"Sz\u00fccs","sequence":"additional","affiliation":[{"name":"First Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e1ndor","family":"Paku","sequence":"additional","affiliation":[{"name":"First Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary"},{"name":"Tumor Progression Research Group Joint Research Organization of the Hungarian Academy of Sciences and Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Nagy","sequence":"additional","affiliation":[{"name":"First Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Dezs\u0151","sequence":"additional","affiliation":[{"name":"First Department of Pathology and Experimental Cancer Research Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2453"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI66026"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-121808-102144"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5291.1379"},{"key":"e_1_2_7_6_1","first-page":"439","article-title":"Ductular reaction after submassive necrosis in humans. 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