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This study compared the extension of <jats:styled-content style=\"fixed-case\">ALI<\/jats:styled-content> in response to intraperitoneal lipopolysaccharide (<jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>) injection in Wistar rats with and without emphysema induced by elastase. Adult male Wistar rats were randomized into four groups: control, emphysema without sepsis, normal lung with sepsis and emphysema with sepsis. Sepsis was induced, and 24 h later the rats were euthanised. The following analysis was performed: blood gas measurements, bronchoalveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>), lung permeability and histology. Animals that received <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content> showed significant increase in a lung injury scoring system, inflammatory cells in bronchoalveolar lavage (<jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>2 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression in lung tissue. Animals with emphysema and sepsis showed increased alveolocapillary membrane permeability, demonstrated by higher <jats:styled-content style=\"fixed-case\">BAL<\/jats:styled-content>\/serum albumin ratio. In conclusion, the presence of emphysema induced by elastase increases the inflammatory response in the lungs to a systemic stimulus, represented in this model by the intraperitoneal injection of <jats:styled-content style=\"fixed-case\">LPS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iep.12214","type":"journal-article","created":{"date-parts":[[2016,12,24]],"date-time":"2016-12-24T19:11:57Z","timestamp":1482606717000},"page":"430-437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Emphysema induced by elastase enhances acute inflammatory pulmonary response to intraperitoneal <scp>LPS<\/scp> in rats"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9624-2359","authenticated-orcid":false,"given":"L\u00eddia Maria Carneiro","family":"da Fonseca","sequence":"first","affiliation":[{"name":"Pulmonary Research Laboratory Universidade Federal de Juiz de Fora Juiz de Fora Brazil"},{"name":"Center of Reproductive Biology Universidade Federal de Juiz de Fora Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maycon Moura","family":"Reboredo","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory Universidade Federal de Juiz de Fora Juiz de Fora Brazil"},{"name":"Center of Reproductive Biology Universidade Federal de Juiz de Fora Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leda Mar\u00edlia Fonseca","family":"Lucinda","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory Universidade Federal de Juiz de Fora Juiz de Fora Brazil"},{"name":"Center of Reproductive Biology Universidade Federal de Juiz de Fora Juiz de Fora Brazil"},{"name":"Department of Morphology Institute of Biological Sciences Universidade Federal de Juiz de Fora Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tha\u00eds Fernanda","family":"Fazza","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory Universidade Federal de Juiz de Fora Juiz de Fora Brazil"},{"name":"Center of Reproductive Biology Universidade Federal de Juiz de Fora Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida Esteves","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory Universidade Federal de Juiz de Fora Juiz de Fora Brazil"},{"name":"Department of Morphology Institute of Biological Sciences Universidade Federal de Juiz de Fora Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adenilson Souza","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Department of Biophysics and Biometry Institute of Biology Roberto Alcantara Gomes Universidade do Estado do Rio de Janeiro Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"de Paoli","sequence":"additional","affiliation":[{"name":"Department of Morphology Institute of Biological Sciences Universidade Federal de Juiz de Fora Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Valle","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Pulmonary Research Laboratory Universidade Federal de Juiz de Fora Juiz de Fora Brazil"},{"name":"Center of Reproductive Biology Universidade Federal de Juiz de Fora Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200611-1739OC"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2062"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201011-1802OC"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.17.4.320"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.5.7582312"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00930.x"},{"key":"e_1_2_8_8_1","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLDz)(2015) \u2010Global Strategy for the Diagnosis Management and Prevention of COPD.http:\/\/www.goldcopd.org\/guidelines-global-strategy-for-diagnosis-management.html\/(accessed 12.06.15)."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/15412550903341513"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-200204000-00010"},{"key":"e_1_2_8_11_1","first-page":"597","article-title":"Continuing to Confront COPD International Patient Survey: methods, COPD prevalence, and disease burden in 2012\u20102013","volume":"9","author":"Landis S.H.","year":"2014","journal-title":"Int. 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