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Male<jats:italic>Wistar<\/jats:italic>rats (<jats:italic>n<\/jats:italic>\u00a0=\u00a06\/per group) received an intraperitoneal Cd injection (1.2\u00a0mg\/Kg) at age 80\u00a0days and<jats:styled-content style=\"fixed-case\">GJC<\/jats:styled-content>(2\u00a0g\/Kg) by gavage from 50\u00a0days until 136\u00a0days old. Groups receiving either Cd or<jats:styled-content style=\"fixed-case\">GJC<\/jats:styled-content>were added. An intraperitoneal injection of saline (0.9%) and water by gavage was administered in the absence of treatment with Cd or<jats:styled-content style=\"fixed-case\">GJC<\/jats:styled-content>. Animals were anaesthetized and exsanguinated at 136\u00a0days; the vas deferens, left testis and epididymis were removed; and perfusion continued with fixative. The right epididymis was collected for morphological analysis. Cd had a devastating effect demonstrated by reduced sperm count in testes and epididymis, sperm production and normal sperm count, besides increased epididymis sperm transit time and completely disorganized morphology. These alterations were attributed to higher Cd levels in the testes and a lipid peroxidation (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) process. Consumption of<jats:styled-content style=\"fixed-case\">GJC<\/jats:styled-content>plus Cd intoxication was effective, reducing metal accumulation and<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>. Consequently, we could identify a preserved sperm profile, with improvement in testis and epididymis sperm count, normal sperm structure and sperm transit time. Moreover,<jats:styled-content style=\"fixed-case\">GJC<\/jats:styled-content>extends its protective effect to the epididymis, allowing complete re\u2010establishment of its morphology, ensuring successful sperm maturation process. In conclusion, our study indicates long\u2010term<jats:styled-content style=\"fixed-case\">GJC<\/jats:styled-content>as a promising therapy against reproductive chemical intoxication injury damage, preserving sperm prior to ejaculation.<\/jats:p>","DOI":"10.1111\/iep.12227","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T09:12:54Z","timestamp":1496653974000},"page":"86-99","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Grape juice concentrate alleviates epididymis and sperm damage in cadmium\u2010intoxicated rats"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7808-0800","authenticated-orcid":false,"given":"Celina de A.","family":"Lamas","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute State University of Campinas Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Cuquetto\u2010Leite","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute State University of Campinas Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanueli","family":"do Nascimento da Silva","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Chemistry Institute State University of Campinas Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna F.","family":"Thomazini","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute State University of Campinas Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel da S.","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Biological Science State University of Paran\u00e1 \u2013 Campus Paranagu\u00e1 Paranagu\u00e1 PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabr\u00edcia de S.","family":"Predes","sequence":"additional","affiliation":[{"name":"Department of Biological Science State University of Paran\u00e1 \u2013 Campus Paranagu\u00e1 Paranagu\u00e1 PR Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea P.B.","family":"Goll\u00fccke","sequence":"additional","affiliation":[{"name":"Department of Biosciences Federal University of Sao Paulo Santos SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Dolder","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology Biology Institute State University of Campinas Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.2.8177"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2004.03.015"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(02)00081-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510004368"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3186"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-010-9426-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.11606\/T.5.2006.tde-05012007-172357"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401630310"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401660210"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/6.1.65"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/ng0501-82","article-title":"Haploinsufficiency of protamine\u20101 or \u20102 causes infertility in mice","volume":"28","author":"Cho C.","year":"2011","journal-title":"Nat. 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