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Its agent, <jats:italic>Toxoplasma gondii<\/jats:italic>, causes a severe innate pro\u2010inflammatory response. The indigenous intestinal microbiota promotes host animal homoeostasis and may protect the host against pathogens. Germ\u2010free (<jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content>) animals provide an important tool for the study of interactions between host and microbiota. In this study, we assessed the role of indigenous microorganisms in disease development utilizing a murine toxoplasmosis model, which includes conventional (<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">GF NIH<\/jats:styled-content> Swiss mice. <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> mice orally inoculated with <jats:italic>T.\u00a0gondii<\/jats:italic> had similar survival curves. However, disease developed differently in the two animal groups. In <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> mice, intestinal permeability increased and levels of intestinal pro\u2010inflammatory cytokines were altered. In <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> animals, there were discrete epithelial degenerative changes and mucosal oedema, but the liver and lungs displayed significant lesions. We conclude that, despite similar survival curves, <jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content> animals succumb to an exaggerated inflammatory response, whereas <jats:styled-content style=\"fixed-case\">GF<\/jats:styled-content> mice fail to produce an adequate systemic response.<\/jats:p>","DOI":"10.1111\/iep.12236","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T04:58:30Z","timestamp":1505192310000},"page":"191-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Influence of indigenous microbiota on experimental toxoplasmosis in conventional and germ\u2010free mice"],"prefix":"10.1111","volume":"98","author":[{"given":"Bruna B.","family":"Nascimento","sequence":"first","affiliation":[{"name":"Departamento de Patologia Geral Laborat\u00f3rio de Neuro\u2010Imunopatologia Experimental (NIPE) Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane T.","family":"Cartelle","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral Laborat\u00f3rio de Neuro\u2010Imunopatologia Experimental (NIPE) Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de L.","family":"Noviello","sequence":"additional","affiliation":[{"name":"Departamento de Patologia Geral Laborat\u00f3rio de Neuro\u2010Imunopatologia Experimental (NIPE) Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breno V.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo W.","family":"de Almeida Vitor","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle da G.","family":"Souza","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"de Vasconcelos Generoso","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valbert N.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaviano dos S.","family":"Martins","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques R.","family":"Nicoli","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia Instituto de Ci\u00eancias Biol\u00f3gicas Universidade Federal de Minas Gerais Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-9717","authenticated-orcid":false,"given":"Rosa M. 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