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We assessed behavioural changes in rats fed diets enriched in fat and fructose in different proportions and correlated the observed alterations with biochemical changes induced by the diets. Three groups of rats were used as follows: control (C) animals fed regular rat chow, rats fed high\u2010fat diet (\n                    <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                    ) and rats fed high\u2010fat and high\u2010fructose diet (\n                    <jats:styled-content style=\"fixed-case\">HFHF<\/jats:styled-content>\n                    ).\n                    <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">HFHF<\/jats:styled-content>\n                    animals were also given a 10% fructose solution as drinking water. Behavioural and biochemical parameters were determined. Anxiety was measured by the open\u2010field and the social interaction test. Depression\u2010like behaviour was evaluated by the forced swimming test. The object recognition test was utilized to assess effects on memory. Diet\u2010exposed animals displayed signs of anxiety in the open\u2010field (\n                    <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                    rats had reduced central time;\n                    <jats:styled-content style=\"fixed-case\">HFHF<\/jats:styled-content>\n                    rats had reduced number of central entries) and in the social interaction test (decreased time of interaction in\n                    <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n                    group). In the forced swimming test, the immobility time was prolonged in the\n                    <jats:styled-content style=\"fixed-case\">HFHF<\/jats:styled-content>\n                    group. While different measures of anxiety scores correlated with visceral adiposity and dyslipidemia, results from both social interaction and forced swimming tests were significantly associated with lipid peroxidation, which in turn also correlated with the metabolic parameters. The experimental diets did not affect the object recognition memory. Both experimental diets induced metabolic derangements in rats and provoked similar anxiety\u2010 and depression\u2010like behaviours. Lipid peroxidation seems to play a role in translating diet\u2010induced metabolic alterations into behavioural disorders.\n                  <\/jats:p>","DOI":"10.1111\/iep.12254","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T02:12:50Z","timestamp":1512526370000},"page":"296-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Diets rich in saturated fat and fructose induce anxiety and depression\u2010like behaviours in the rat: is there a role for lipid peroxidation?"],"prefix":"10.1111","volume":"98","author":[{"given":"Silvia","family":"Gancheva","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology and Therapeutics Medical University of Varna Varna Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bistra","family":"Galunska","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Molecular Medicine and Nutrigenomics Medical University of Varna Varna Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1132-8813","authenticated-orcid":false,"given":"Maria","family":"Zhelyazkova\u2010Savova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology and Therapeutics Medical University of Varna Varna Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-511X-10-74"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083243"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.05.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.02.055"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.2.7944"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406344101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.09.003"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328356c3f2"},{"key":"e_1_2_8_10_1","first-page":"27","volume-title":"The Object Recognition Task: A New Proposal for the Memory Performance Study","author":"Carlini V.P.","year":"2011"},{"key":"e_1_2_8_11_1","volume-title":"Guide to Research Techniques in Neuroscience (Second Edition)","author":"Carter M.","year":"2015"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000122852.22604.78"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2013.07.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.05.032"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.079632"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.08.019"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-4328(88)90157-X"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1978.tb07001.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1179\/1476830513Y.0000000092"},{"key":"e_1_2_8_20_1","unstructured":"GajdaA. 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