{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:32:53Z","timestamp":1784637173405,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T00:00:00Z","timestamp":1516320000000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with Chagas\u2019 disease may develop dysfunctions of oesophageal and colonic motility resulting from the degeneration or loss of the myenteric neurons of the enteric nervous system. Studies have shown that the use of aspirin, also known as acetylsalicylic acid (<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>), influences the pathogenesis of the disease. However, this remains controversial. The aim of this study was to evaluate the consequences of treatment with low doses of aspirin during the chronic phase of Chagas\u2019 disease on oesophageal function. Twenty male Swiss mice, 60\u00a0days of age, were used. The animals were infected with Y strain of <jats:italic>Trypanosoma cruzi,<\/jats:italic> injected intraperitoneally. Aspirin was given at a dose of 50\u00a0mg\/kg to some of the infected animals, from the 55th to 63rd day after inoculation on consecutive days, and from the 65th to 75th day on alternate days. We investigated food passage of time, wall structure and nitrergic neuronal population of the distal oesophagus. Our data revealed that the use of low doses of aspirin in chronic Chagas\u2019 disease caused an increase in the number of nitrergic neurons and partially prevented hypertrophy of the oesophagus. In addition, the aspirin administration impeded Chagas' diseases associated changes in intestinal transit time. Thus treatment with aspirin in the chronic phase of Chagas\u2019 disease changes the natural history of the disease and raises the possibility of using it as a new therapeutic approach to the treatment of this aspect of Chagas' disease pathology.<\/jats:p>","DOI":"10.1111\/iep.12259","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T10:47:23Z","timestamp":1516358843000},"page":"356-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Treatment with low doses of aspirin during chronic phase of experimental Chagas\u2019 disease increases oesophageal nitrergic neuronal subpopulation in mice"],"prefix":"10.1111","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7251-1625","authenticated-orcid":false,"given":"Cristina Lorena","family":"Massocatto","sequence":"first","affiliation":[{"name":"University Center Integrado Campo Mour\u00e3o Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neide","family":"Martins Moreira","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Muniz","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Marques de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phileno","family":"Pinge\u2010filho","sequence":"additional","affiliation":[{"name":"Department of Pathological Sciences State University of Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson Marcelo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Statistics State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Jos\u00e9","family":"de Almeida Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Department of Histology State University of Londrina Londrina Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"de Mello Gon\u00e7ales Sant'ana","sequence":"additional","affiliation":[{"name":"Department of Morphological Sciences State University of Maring\u00e1 Maring\u00e1 Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46651991000600004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652014000600013"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022009000300047"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822009000200015"},{"key":"e_1_2_6_6_1","unstructured":"Brasil. 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