{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T19:52:39Z","timestamp":1775677959778,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T00:00:00Z","timestamp":1519344000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008721","name":"University College London Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Non\u2010dysplastic Barrett's oesophagus (<jats:styled-content style=\"fixed-case\">NDBE<\/jats:styled-content>) occurs as a consequence of an inflammatory response triggered through prolonged gastro\u2010oesophageal reflux and it may precede the development of oesophageal adenocarcinoma. <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB activation as a result of the inflammatory response has been shown in <jats:styled-content style=\"fixed-case\">NDBE<\/jats:styled-content>, but the possible mechanism involved in the process is unknown. The aim of this study was to assess, using immunohistochemistry, Survivin and Bcl3 expression as potential biomarkers for <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB activation along the oesophageal metaplasia\u2013dysplasia\u2013adenocarcinoma sequence. Survivin is an <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB\u2010inducible anti\u2010apoptotic protein, and Bcl3 is a negative regulator of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB. There was progressive upregulation of Survivin expression along the oesophageal metaplasia\u2013dysplasia\u2013adenocarcinoma sequence. Bcl3 expression was upregulated in non\u2010dysplastic Barrett's oesophagus, low\u2010grade, high\u2010grade dysplasia and oesophageal adenocarcinoma when compared to squamous group. The study shows the differential expression of Bcl3 between the squamous and Barrett's stage, suggesting that Bcl3 could be a surrogate marker for early event involving constitutive <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB activation. In addition, the study suggests that <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB activation may infer resistance to apoptosis through the expression of anti\u2010apoptotic genes such as Survivin, which showed progressive increase in expression throughout the oesophageal metaplasia\u2013dysplasia\u2013adenocarcinoma sequence. This ability to avoid apoptosis may underlie the persistence and malignant predisposition of Barrett's metaplasia.<\/jats:p>","DOI":"10.1111\/iep.12260","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T08:42:37Z","timestamp":1519375357000},"page":"10-14","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immunohistochemical assessment of Survivin and Bcl3 expression as potential biomarkers for <scp>NF<\/scp>\u2010\u03baB activation in the Barrett metaplasia\u2013dysplasia\u2013adenocarcinoma sequence"],"prefix":"10.1111","volume":"99","author":[{"given":"Ignazio","family":"Puccio","sequence":"first","affiliation":[{"name":"Research Department of Tissue and Energy Division of Surgery &amp; Interventional Science University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif","family":"Khan","sequence":"additional","affiliation":[{"name":"Research Department of Tissue and Energy Division of Surgery &amp; Interventional Science University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Butt","sequence":"additional","affiliation":[{"name":"Research Department of Tissue and Energy Division of Surgery &amp; Interventional Science University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Graham","sequence":"additional","affiliation":[{"name":"Research Department of Tissue and Energy Division of Surgery &amp; Interventional Science University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinay","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Research Department of Tissue and Energy Division of Surgery &amp; Interventional Science University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominic","family":"Patel","sequence":"additional","affiliation":[{"name":"Research Department of Tissue and Energy Division of Surgery &amp; Interventional Science University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Novelli","sequence":"additional","affiliation":[{"name":"Research Department of Pathology University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence B.","family":"Lovat","sequence":"additional","affiliation":[{"name":"Research Department of Tissue and Energy Division of Surgery &amp; Interventional Science University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Rodriguez\u2010Justo","sequence":"additional","affiliation":[{"name":"Research Department of Pathology University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6630-4814","authenticated-orcid":false,"given":"Rifat A.","family":"Hamoudi","sequence":"additional","affiliation":[{"name":"Research Department of Tissue and Energy Division of Surgery &amp; Interventional Science University College London London UK"},{"name":"Sharjah Institute for Medical Research College of Medicine University of Sharjah Sharjah United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000118751.95179.c6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.175"},{"issue":"2","key":"e_1_2_9_4_1","first-page":"155","article-title":"Prognostic and predictive factors in breast cancer by immunohistochemical analysis","volume":"11","author":"Allred D.C.","year":"1998","journal-title":"Mod. Pathol."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81318-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1026529"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7865"},{"issue":"1","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/clinchem\/45.1.7","article-title":"New insights into the role of nuclear factor\u2010kappaB, a ubiquitous transcription factor in the initiation of diseases","volume":"45","author":"Chen F.","year":"1999","journal-title":"Clin. Chem."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203412"},{"key":"e_1_2_9_10_1","unstructured":"CRUK oesophageal cancer statistics(http:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/oesophageal-cancer) [http:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/oesophageal-cancer]"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10365439"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-141"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-3703"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20954"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.3579"},{"issue":"20","key":"e_1_2_9_16_1","first-page":"1","article-title":"Survivin\u2010specific CD4\u00a0+\u00a0 T cells are decreased in patients with survivin\u2010positive myeloma","volume":"3","author":"Locke F.L.","year":"2015","journal-title":"J. Immunother. Cancer"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5377"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41338.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1666"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji024"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15069"},{"issue":"341","key":"e_1_2_9_22_1","first-page":"1","article-title":"Early diagnostic value of Bcl\u20103 localization in colorectal cancer","volume":"15","author":"Saamarthy K.","year":"2015","journal-title":"BMC Cancer"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2008.30"},{"issue":"23","key":"e_1_2_9_24_1","first-page":"8293","article-title":"Activation of nuclear factor\u2010kappaB p50 homodimer\/Bcl\u20103 complexes in nasopharyngeal carcinoma","volume":"63","author":"Thornburg N.J.","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.08.008"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031588"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2003.12.003"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S118184"}],"container-title":["International Journal of Experimental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiep.12260","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:29:51Z","timestamp":1695565791000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iep.12260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/iep.12260"],"URL":"https:\/\/doi.org\/10.1111\/iep.12260","archive":["Portico"],"relation":{},"ISSN":["0959-9673","1365-2613"],"issn-type":[{"value":"0959-9673","type":"print"},{"value":"1365-2613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"2017-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}