{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:00:11Z","timestamp":1788188411184,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T00:00:00Z","timestamp":1519603200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although there is emerging evidence that mast cells are involved in infertility, their exact role has not been elucidated clearly. Here we carried out a retrospective case\u2013control study to find out whether there is a correlation between mast cell (<jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>) count and proliferation (Ki67 index) of the spermatogenic epithelium as well as of the Sertoli cells (vimentin\u2010positive) in non\u2010obstructive azoospermia (<jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content>). We assessed <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content>s, Ki67 and vimentin expression in Sertoli cells in testicular biopsies of germ cell aplasia (<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>,<jats:italic> n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>14) and maturation arrest (<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>,<jats:italic> n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>14) <jats:italic>vs<\/jats:italic>. normal spermatogenesis (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>14) cases. There was a significant decrease in the spermatogonial Ki67 index (1.25\u00a0\u00b1\u00a00.91, 4.21\u00a0\u00b1\u00a01.81 <jats:italic>vs<\/jats:italic>. 39.57\u00a0\u00b1\u00a03.92) and Johnsen score (2.48\u00a0\u00b1\u00a00.65, 4.89\u00a0\u00b1\u00a01.05 <jats:italic>vs<\/jats:italic>. 9.75\u00a0\u00b1\u00a00.30) as well as a significant increase (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) in <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> count (29.00\u00a0\u00b1\u00a04.11, 7.57\u00a0\u00b1\u00a01.95 <jats:italic>vs<\/jats:italic>. 3.00\u00a0\u00b1\u00a01.30) in seminiferous tubules of infertile cases with <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MA <\/jats:styled-content><jats:italic>vs<\/jats:italic>. controls. On the other hand, the percentage of vimentin\u2010expressing Sertoli cells was significantly decreased (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) in biopsies of cases with <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> (35.50\u00a0\u00b1\u00a015.62) compared to those of cases with <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> and controls (72.64\u00a0\u00b1\u00a010.67 and 98.57\u00a0\u00b1\u00a01.45 respectively). Additionally, a significant negative correlation was detected between <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> count and Ki67 index as well as Johnsen score in the <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> group which became more significant in the <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> group. The significant increase in <jats:styled-content style=\"fixed-case\">MC<\/jats:styled-content> count in the <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> group and to a lesser extent in the <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> group indicates their possible role in <jats:styled-content style=\"fixed-case\">NOA<\/jats:styled-content> particularly at the spermatogonial proliferation level and this is supported by the significant negative correlation with the Ki67 index.<\/jats:p>","DOI":"10.1111\/iep.12261","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T06:12:57Z","timestamp":1519625577000},"page":"22-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Correlation between testicular mast cell count and spermatogenic epithelium in non\u2010obstructive azoospermia"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-4609","authenticated-orcid":false,"given":"Ahmed A. M.","family":"Abdel\u2010Hamid","sequence":"first","affiliation":[{"name":"Department of Histology and Cell Biology Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Atef","sequence":"additional","affiliation":[{"name":"Department of Histology and Cell Biology Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled R.","family":"Zalata","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atef","family":"Abdel\u2010Latif","sequence":"additional","affiliation":[{"name":"Department of General Surgery Mansoura University Hospitals Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-016-9664-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2016.06.002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2016.01.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12196"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2017.02.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der245"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2008.00879.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.11.2269"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/01485010290099183"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4344-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)02161-7"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.08.059"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2007.00795.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-14-0392"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2010.01083.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1586\/eci.11.57"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/2348-3334.149350"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.125"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.05163.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"crossref","first-page":"S512","DOI":"10.4103\/2230-8210.104154","article-title":"Sertoli cell only syndrome: Status of sertoli cell maturation and function","volume":"16","author":"Jain M.","year":"2012","journal-title":"Indian J. 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