{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:46:32Z","timestamp":1773884792672,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T00:00:00Z","timestamp":1537920000000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The National Committee for Evaluation and Programming of University Research (C.N.E.P.R.U.) of the Algerian Government","award":["F00220130075"],"award-info":[{"award-number":["F00220130075"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study was designed to investigate the <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content>\u2010axis impairment in the streptozotocin (<jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content>)\u2010diabetic gerbils (<jats:italic>Gerbillus gerbillus<\/jats:italic>). Twenty\u2010six male gerbils (body weight ~27\u00a0g) were divided into 3 groups: vehicle control (n\u00a0=\u00a010), 2\u00a0days of diabetes (n\u00a0=\u00a009) and 30\u00a0days of diabetes (n\u00a0=\u00a007). The latter 2 groups received an intraperitoneal injection of <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content> (150\u00a0mg\/kg of body weight). At 2 and 30\u00a0days of diabetes, streptozotocin\u2010diabetic gerbils underwent a retro\u2010orbital puncture for assessment of biochemical and hormonal parameters. Subsequently the animals were decapitated and the adrenal glands were removed, weighed and processed for light microscopy and stereology. Nondiabetic control gerbils that had been injected with citrate buffer were examined as a comparison. At 2\u00a0days of diabetes, <jats:styled-content style=\"fixed-case\">STZ<\/jats:styled-content> gerbils exhibited symptoms that are characteristic of human diabetes type 1. The adrenal gland showed significant increase in weight, associated with a larger cortex layer, hypertrophy of the fasciculate cells and a significant decrease in the nucleocytoplasmic index. These changes were associated with higher plasma <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> and cortisol concentrations compared to nondiabetic controls. At 30\u00a0days postdiabetes, <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content> levels remained elevated, whereas cortisol levels decreased compared to the early stage of diabetes. Histological analysis revealed the existence of a band of connective tissue (collagen) that separates the cortical and medullary zones and is not present in humans or laboratory rodents, which represents a striking change seen throughout the disease. STZ\u2010induced diabetes mellitus in <jats:italic>Gerbillus gerbillus<\/jats:italic> resulted in hyperactivation of the <jats:styled-content style=\"fixed-case\">HPA<\/jats:styled-content> axis in the early stages of diabetes mellitus which did not persist into the final stages of the disease, suggesting a possible reduction in adrenocortical sensitivity over time.<\/jats:p>","DOI":"10.1111\/iep.12284","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T13:02:26Z","timestamp":1537966946000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hyperactivation of the hypothalamo\u2010pituitary\u2010adrenocortical axis in streptozotocin\u2010diabetic gerbils (<i>Gerbillus gerbillus<\/i>)"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-9621","authenticated-orcid":false,"given":"Soumia","family":"Hammadi","sequence":"first","affiliation":[{"name":"Department of Biology and Physiology of Organisms (LBPO) Nutrition\u2010Metabolism\/FSB\/USTHB Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Owen","family":"Chan","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine, Metabolism and Diabetes University of Utah School of Medicine Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdellali","sequence":"additional","affiliation":[{"name":"Service of Pathology and Anatomy CHU Hussein Dey: Ex: Parnet Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha","family":"Medjerab","sequence":"additional","affiliation":[{"name":"Department of Biology and Physiology of Organisms (LBPO) Nutrition\u2010Metabolism\/FSB\/USTHB Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadjer","family":"Agoun","sequence":"additional","affiliation":[{"name":"Department of Biology and Physiology of Organisms (LBPO) Nutrition\u2010Metabolism\/FSB\/USTHB Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zineb","family":"Bellahreche","sequence":"additional","affiliation":[{"name":"Department of Biology and Physiology of Organisms (LBPO) Nutrition\u2010Metabolism\/FSB\/USTHB Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Khalkhal","sequence":"additional","affiliation":[{"name":"Department of Biology and Physiology of Organisms (LBPO) Nutrition\u2010Metabolism\/FSB\/USTHB Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmina","family":"Dahmani","sequence":"additional","affiliation":[{"name":"Department of Biology and Physiology of Organisms (LBPO) Nutrition\u2010Metabolism\/FSB\/USTHB Algiers Algeria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,26]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"87","article-title":"Diabetes and the hypothalamo\u2010pituitary\u2010adrenal (HPA) axis","volume":"28","author":"Chan O","year":"2003","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.20.11056"},{"key":"e_1_2_8_4_1","first-page":"1","article-title":"From type\u20101 diabetes HPA axis to the disease complications","volume":"12","author":"Torres RC","year":"2013","journal-title":"J Diabetes Metab"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1093620"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.01790220080013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.5.8809"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.11.8474"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0592"},{"issue":"4","key":"e_1_2_8_10_1","first-page":"375","article-title":"Morpho\u2010functional changes of pituitary\u2010adrenal system in the long\u2010term course of experimental diabetes mellitus","volume":"6","author":"Yurii T","year":"2016","journal-title":"J Educ Health Sport"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-12-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1340"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.9.7001"},{"key":"e_1_2_8_14_1","unstructured":"PouletS. (2004)La gerbille un nouveau rongeur de compagnie. Doctoral thesis. Thesis director; Jacques Ducos de lahitte. Touleuse 3. National school of veterinary. 4041.150 p."},{"issue":"4","key":"e_1_2_8_15_1","first-page":"299","article-title":"Adrenal Glandular Lipids And Circulating Corticosterone In Severely Diabetic Rats","volume":"56","author":"Wexler BC","year":"1975","journal-title":"Int J Exp Pathol"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.978"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01911.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01499.x"},{"issue":"5","key":"e_1_2_8_19_1","first-page":"348","article-title":"Mechanisms of impaired hypothalamic\u2010pituitary\u2010adrenal (HPA) function in diabetes: reduced counter regulatory responsiveness","volume":"15","author":"Inouye K","year":"2002","journal-title":"Diabetes Nutr Metab"},{"issue":"4","key":"e_1_2_8_20_1","first-page":"269","article-title":"Morphometric and histological studies on the adrenal glands of the camel Camelus dromedarius","volume":"26","author":"Abdalla MA","year":"1988","journal-title":"Acta Morphol Neerl Scand"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.9.2217"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-6-1491"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1297.024"},{"issue":"6","key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.MCHD-0048-2016","article-title":"Macrophages in endocrine glands with emphasis on pancreatic islets","volume":"4","author":"Unanue ER","year":"2016","journal-title":"Microbiol Spectr"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.12.025"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111600109"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02889996"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1093502"},{"issue":"1358","key":"e_1_2_8_29_1","first-page":"22","article-title":"Adrenal gland volume and dexamethasone\u2010suppressed cortisol correlate with total daily salivary cortisol in African\u2010American women","volume":"92","author":"Golden SH","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470987117.ch15"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.7.2962"},{"issue":"4","key":"e_1_2_8_32_1","first-page":"843","article-title":"The effect of l\u2010arginine and insulin on histological changes in streptozotocin treated rat adrenal gland","volume":"6","author":"Mahar Y","year":"2012","journal-title":"Pak J Med Health Sci"},{"issue":"2","key":"e_1_2_8_33_1","first-page":"81","article-title":"Characterisation of streptozotocin induced diabetes mellitus in Swiss albino mice","volume":"3","author":"Sachin A","year":"2009","journal-title":"Global J Pharmacol"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1444-2892.2003.00160.x"},{"issue":"3","key":"e_1_2_8_35_1","first-page":"120","article-title":"Adrenocortical insufficiency and\u00a0diabetes mellitus type 1","volume":"149","author":"Sim\u016fnkov\u00e1 K","year":"2010","journal-title":"Cas Lek Cesk"}],"container-title":["International Journal of Experimental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiep.12284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T18:03:18Z","timestamp":1694973798000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iep.12284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/iep.12284"],"URL":"https:\/\/doi.org\/10.1111\/iep.12284","archive":["Portico"],"relation":{},"ISSN":["0959-9673","1365-2613"],"issn-type":[{"value":"0959-9673","type":"print"},{"value":"1365-2613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"2017-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}