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However, when antigens are sampled in an inflammatory setting, the immune response may either be protective, in the case of harmful pathogens, or cause further inflammatory reactions as in food allergy, inflammatory bowel diseases, coeliac disease or food protein\u2010induced enterocolitis syndrome. Therefore, there is a need for accurate and consistent experimental models. However, a drawback in comparing these models is the lack of a classification system similar to that which is already used for humans. Thus, the aim of this work was to propose a classification system of the small intestinal histomorphology in experimental mice. To do this we used a mouse antigen\u2010specific gut inflammation model developed by our research group. Duodenum sections stained with haematoxylin\u2010eosin and Alcian blue were scanned using the <jats:styled-content style=\"fixed-case\">APERIO<\/jats:styled-content> scanning system and analysed with the ImageScope<jats:sup>\u00ae<\/jats:sup> software. The evaluated parameters were villus area, villus height and width, enterocyte count, mononuclear intra\u2010epithelial leucocyte and goblet cell counts, and architectural and cellular ratios. Food\u2010sensitized animals challenged with a diet containing the corresponding food allergen presented, as for humans, time\u2010dependent shortened and widened villi accompanied by leucocyte infiltrate and loss of goblet cells. With these data, we were able to establish a classification system for experimental intestinal inflammation in mice thus permitting better comparisons among and between experiments than has been possible previously.<\/jats:p>","DOI":"10.1111\/iep.12286","type":"journal-article","created":{"date-parts":[[2018,9,3]],"date-time":"2018-09-03T06:05:00Z","timestamp":1535954700000},"page":"189-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A histomorphometric classification system for normal and inflamed mouse duodenum\u2014Quali\u2010quantitative approach"],"prefix":"10.1111","volume":"99","author":[{"given":"Airton","family":"Pereira e Silva","sequence":"first","affiliation":[{"name":"Gastrointestinal Immunology Group Department of Immunobiology Institute of Biology Federal Fluminense University Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Graduate Program in Pathology, Medicine School Ant\u00f4nio Pedro Hospital Federal Fluminense University Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o R. 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