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The components from bothropic venom are responsible for many systemic clinical complications resulting from envenomation. The present work aimed to analyse the systemic changes induced in mice after intraperitoneal administration of Bmoo<jats:styled-content style=\"fixed-case\">TX<\/jats:styled-content>\u2010I, a myotoxic acidic phospholipase A<jats:sub>2<\/jats:sub> isolated from <jats:italic>Bothrops moojeni<\/jats:italic> venom. Urinalysis was performed and the following plasma biochemical markers were documented: urea, creatinine and uric acid (renal function); glucose and amylase (pancreatic function); alanine aminotransferase, alkaline phosphatase and gamma\u2010<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> (intra\u2010 and extrahepatic function); creatine kinase and enzymatic lactate (muscle function). Our results showed that after the intraperitoneal injection of Bmoo<jats:styled-content style=\"fixed-case\">TX<\/jats:styled-content>\u2010I the urine of these animals showed glycosuria, proteinuria, haematuria, bacteriuria, bilirubinuria, polyuria and nitrite. The plasma biochemical analysis showed alterations in levels of urea, creatinine and uric acid. Amylase concentration was not altered significantly, but the plasma glucose increased significantly compared to controls. The plasma levels of alanine aminotransferase and alkaline phosphatase decreased and increased, respectively, in these same animals. On the other hand, the plasma \u03b3<jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> concentration did not undergo significant modification compared to the control group. The plasma concentration of <jats:styled-content style=\"fixed-case\">CK<\/jats:styled-content> increased, while the enzymatic lactate concentration decreased after the injection of the Bmoo<jats:styled-content style=\"fixed-case\">TX<\/jats:styled-content>\u2010I. Therefore, in mice Bmoo<jats:styled-content style=\"fixed-case\">TX<\/jats:styled-content>\u2010I is capable of causing systemic alterations which manifest as renal, muscular, hepatic and pancreatic impairment.<\/jats:p>","DOI":"10.1111\/iep.12290","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T09:12:16Z","timestamp":1542705136000},"page":"226-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systemic alterations induced by phospholipase A<sub>2<\/sub>, Bmoo<scp>TX<\/scp>\u2010I, isolated from <i>Bothrops moojeni<\/i> snake venom"],"prefix":"10.1111","volume":"99","author":[{"given":"Kellen Cristina Torres","family":"Costa","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas Universidade Federal de Uberl\u00e2ndia Uberl\u00e2ndia MG Brazil"},{"name":"Instituto de Gen\u00e9tica e Bioqu\u00edmica Universidade Federal de Uberl\u00e2ndia 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