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In view of the lack of knowledge about the pathogenesis of the disease pattern caused by <jats:italic>L. (L) infantum chagasi<\/jats:italic> in individuals affected by <jats:styled-content style=\"fixed-case\">NUCL<\/jats:styled-content>, the aim of the present study was to describe in detail the histopathological features of the skin lesion caused by the parasite. Biopsies from human NUCL lesions with a positive parasitological diagnosis were collected and processed using standard histological techniques. Paraffin sections stained by haematoxylin and eosin were used to examine the histopathological alterations seen in the skin. The lesions varied between 3 and 5\u00a0mm, and the majority of the patients (60%) had a single lesion. Lesions were more frequently seen in females (65%), with an average age of 33.4\u00a0years. Microscopically, the skin lesions were characterized by mononuclear inflammatory infiltrate in the dermis composed of lymphocytes, macrophages and a few plasma cells. The intensity of the infiltration varied from discrete to intense. In both cases, the parasitic infection was discrete. Granulomas were present in 60% of cases and were associated with intense inflammation. The data revealed by the histopathological alterations in the skin of individuals affected by <jats:styled-content style=\"fixed-case\">NUCL<\/jats:styled-content> suggest activation of a cellular immune response that potentially controls parasite spreading.<\/jats:p>","DOI":"10.1111\/iep.12295","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T09:13:23Z","timestamp":1543310003000},"page":"249-257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Histopathological features of skin lesions in patients affected by non\u2010ulcerated or atypical cutaneous leishmaniasis in Honduras, Central America"],"prefix":"10.1111","volume":"99","author":[{"given":"Carmen Maria","family":"Sandoval Pacheco","sequence":"first","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Venicia","family":"Araujo Flores","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurea","family":"Favero Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases LIM50 Clinical Hospital HCFMUSP Medical School S\u00e3o Paulo University  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfredo","family":"Sosa Ochoa","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University  S\u00e3o Paulo SP Brazil"},{"name":"Microbiology Research Institute National Autonomous University of Honduras  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia L\u00facia","family":"Ribeiro da Matta","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases LIM50 Clinical Hospital HCFMUSP Medical School S\u00e3o Paulo University  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Z\u00faniga Valeriano","sequence":"additional","affiliation":[{"name":"Department of Health Surveillance University School Hospital  Tegucigalpa Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Pereira Corbett","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia","family":"Dalastra Laurenti","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology of Infectious Diseases Medical School S\u00e3o Paulo University  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.61.380"},{"key":"e_1_2_7_3_1","first-page":"33","article-title":"Leishmaniasis en El Salvador","volume":"4","author":"Cedillos RA","year":"2014","journal-title":"Minerva Revista en l\u00ednea CIC\u2010UES Enero\u2010Julio"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90734-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90328-3"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"7","article-title":"Caracterizaci\u00f3n cl\u00ednico\u2010epidemiol\u00f3gica de pacientes con leishmaniasis atendidos en el Hospital Escuela","volume":"77","author":"Matute N","year":"2009","journal-title":"Rev Med HONDUR"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"47","article-title":"Estudio Cl\u00ednico\u2010epidemiol\u00f3gico de leishmaniasis cut\u00e1nea at\u00edpica en Reitoca, zona end\u00e9mica del sur de Honduras","volume":"9","author":"Santos K","year":"2006","journal-title":"Revista M\u00e9dica de los Post Grados de Med UNAH"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1996.4133"},{"key":"e_1_2_7_9_1","volume-title":"Manual de manejo de enfermedades parasitarias prioritarias en Honduras","author":"OPS","year":"2009"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2004.11.013"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3487591"},{"key":"e_1_2_7_12_1","unstructured":"Instituto Nacional de Estadistica Honduras (INE). 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