{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:50:22Z","timestamp":1774464622464,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Acute mesenteric ischaemia is a syndrome caused by inadequate blood flow through the mesenteric vessels, resulting in ischaemia and eventual gangrene of the bowel wall. Although relatively rare, it is a potentially life\u2010threatening condition. The maintenance of haemodynamic stability, along with adequate oxygen saturation, and the correction of any electrolyte imbalance, are of the utmost importance. However, <jats:styled-content style=\"fixed-case\">nicotinamide adenine dinucleotide (NAD)<\/jats:styled-content> biosynthesis modulation by precursor introduction can also be a powerful tool for preventing injury. Nicotinamide riboside is a pyridine\u2010nucleoside form of vitamin B3 that functions as a precursor to <jats:styled-content style=\"fixed-case\">NAD<\/jats:styled-content><jats:sup>+<\/jats:sup>. The present study investigated nicotinamide riboside's effect on endothelium functional state, microcirculation and intestinal morphology in acute mesenteric ischaemia and reperfusion. Mesenteric ischaemia was simulated after the adaptation period (15\u00a0minutes) by occluding the superior mesenteric artery for 60\u00a0minutes, followed by a reperfusion period of 30\u00a0minutes. The functional state of intestinal microcirculation was evaluated by laser Doppler flowmetry. Endothelial functional activity was studied by using wire myography. Intestinal samples were stained with haematoxylin and eosin for histological analysis. The results revealed that nicotinamide riboside protects the intestinal wall from ischaemia\u2010reperfusion injury, as well as improving the relaxation function of mesenteric vessels. Nicotinamide riboside's protective effect in small intestine ischaemia\u2010reperfusion can be used to reduce ischaemia\u2010reperfusion injury, as well as to preserve intestinal grafts until transplant.<\/jats:p>","DOI":"10.1111\/iep.12302","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T02:25:18Z","timestamp":1551147918000},"page":"304-311","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Nicotinamide riboside has protective effects in a rat model of mesenteric ischaemia\u2010reperfusion"],"prefix":"10.1111","volume":"99","author":[{"given":"Yana G.","family":"Toropova","sequence":"first","affiliation":[{"name":"V.A. Almazov National North\u2010West Medical Research Center Ministry of Health of the Russian Federation  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3485-8545","authenticated-orcid":false,"given":"Nadezdha A.","family":"Pechnikova","sequence":"additional","affiliation":[{"name":"V.A. Almazov National North\u2010West Medical Research Center Ministry of Health of the Russian Federation  Saint\u2010Petersburg Russia"},{"name":"Saint\u2010Petersburg State Chemical Pharmaceutical University  Saint\u2010Petersburg Russia"},{"name":"Zoological Institute Russian Academy of Sciences  Universitetskaya Embankment 1Saint Petersburg 199034 Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Zelinskaya","sequence":"additional","affiliation":[{"name":"V.A. Almazov National North\u2010West Medical Research Center Ministry of Health of the Russian Federation  Saint\u2010Petersburg Russia"},{"name":"Saint\u2010Petersburg National Research University of Information Technologies, Mechanics and Optics  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey G.","family":"Zhuravsky","sequence":"additional","affiliation":[{"name":"V.A. Almazov National North\u2010West Medical Research Center Ministry of Health of the Russian Federation  Saint\u2010Petersburg Russia"},{"name":"Pavlov First Saint Petersburg State Medical University Ministry of Health of the Russian Federation  Saint\u2010Petersburg Russia"},{"name":"Research Institute of Influenza Ministry of Health of the Russian Federation  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg V.","family":"Kornyushin","sequence":"additional","affiliation":[{"name":"V.A. 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Almazov National North\u2010West Medical Research Center Ministry of Health of the Russian Federation  Saint\u2010Petersburg Russia"},{"name":"Research Institute of Influenza Ministry of Health of the Russian Federation  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim E.","family":"Karev","sequence":"additional","affiliation":[{"name":"Children's Scientific and Clinical Center of Infectious Diseases Federal Medical and Biological Agency  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina A.","family":"Karabak","sequence":"additional","affiliation":[{"name":"Children's Scientific and Clinical Center of Infectious Diseases Federal Medical and Biological Agency  Saint\u2010Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v7.i1.125"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.08.005"},{"issue":"12948","key":"e_1_2_7_4_1","first-page":"1","article-title":"Nicotinamide riboside is uniquely and orally bioavailable in mice and humans","volume":"7","author":"Trammell SA","year":"2016","journal-title":"Nature Communications"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.120758"},{"issue":"26933","key":"e_1_2_7_6_1","first-page":"1","article-title":"Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice","volume":"6","author":"Trammell SAJ","year":"2016","journal-title":"Scientific Reports"},{"issue":"32","key":"e_1_2_7_7_1","first-page":"1","article-title":"The NAD+ precursor nicotinamide riboside decreases exercise performance in rats","volume":"13","author":"Kourtzidis IA","year":"2016","journal-title":"Journal of the International Society of Sports Nutrition"},{"issue":"5","key":"e_1_2_7_8_1","first-page":"962","article-title":"Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel\u2010induced peripheral neuropathy in female rats","volume":"158","author":"Hamity MV","year":"2017","journal-title":"International Association for the Study of Pain"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.41.1.19"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.5898"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2016.06.014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00024382-199707000-00002"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000042232.98927.91"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2009.03.028"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-010-0727-x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.022"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00416-7"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2679"}],"container-title":["International Journal of Experimental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiep.12302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:01:47Z","timestamp":1694664107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iep.12302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/iep.12302"],"URL":"https:\/\/doi.org\/10.1111\/iep.12302","archive":["Portico"],"relation":{},"ISSN":["0959-9673","1365-2613"],"issn-type":[{"value":"0959-9673","type":"print"},{"value":"1365-2613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"2018-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}