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The altered expression of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in a number of cancers suggests their contribution to disease pathogenesis, where processing pathways may be involved in disease pathogenesis. In the present study, we evaluated changes in the profile of two main components of micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> biogenesis, AGO2 and DICER, and assessed their correlation with disease progression in childhood acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>). To achieve this aim, 25 patients afflicted with <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> were included in the study along with 25 healthy subjects as control. The expression level of AGO2 and DICER was evaluated by real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. The results revealed an increase in the expression of DICER and a decrease in AGO2 in patients. The correlation between the alteration levels of these genes with pathologic events was also studied. This increase or decrease proved to be directly correlated with the progression of the disease particularly in L1 to L2. According to the obtained results, it can be deduced that dysregulation in transcription of DICER and AGO2, involved in the formation of mature micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s in cytoplasm of <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> cancer cells, is a part of the pathological molecular mechanism implicated in the exacerbation of this malignancy. Therefore, the genes involved in micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s biogenesis that have been studied here could be considered as candidate prognostic markers especially in childhood <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> which will help towards a better understanding of the molecular basis of <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iep.12316","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T08:00:13Z","timestamp":1557907213000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The impact of variations in transcription of DICER and AGO2 on exacerbation of childhood B\u2010cell lineage acute lymphoblastic 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