{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:01:18Z","timestamp":1773100878937,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"5-6","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":119,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hyponatraemia is defined as a serum sodium concentration of &lt;135\u00a0mEql\/L and is the most common electrolyte disturbance in patients with chronic heart failure. We hypothesize that hyponatraemia may induce Ca<jats:sup>2+<\/jats:sup> overload and enhance reactive oxygen species (ROS) production, which will exacerbate myocardial injury more than normonatraemia. We investigated the effect of hyponatraemia on the ability of the heart to recover from ischaemia\/reperfusion episodes. Cardiomyocytes were obtained from 1\u2010 to 3\u2010day\u2010old Sprague Dawley rats. After isolation, cardiomyocytes were placed in Dulbecco's modified Eagle's medium (DMEM) containing low sodium concentration (110, 120, or 130\u00a0mEq\/L) or normal sodium concentration (140\u00a0mEq\/L) for 72\u00a0hours. Exposure of cardiomyocytes to each of the low\u2010sodium medium significantly increased both ROS and intracellular Ca<jats:sup>2+<\/jats:sup> levels compared with the exposure to the normal\u2010sodium medium. In vivo, 8\u2010week\u2010old male Sprague Dawley rats were divided into four groups: control group (Con), furosemide group (Fur), low\u2010sodium diet group (Lsd) and both furosemide and low\u2010sodium diet group (Fur\u00a0+\u00a0Lsd). The hearts subjected to global ischaemia exhibited considerable decrease in left ventricular developed pressure during reperfusion, and the size of infarcts induced by ischaemia\/reperfusion significantly increased in the Fur, Lsd and Fur\u00a0+\u00a0Lsd compared with that in the Con. Hyponatraemia aggravates cardiac susceptibility to ischaemia\/reperfusion injury by Ca<jats:sup>2+<\/jats:sup> overload and increasing in ROS levels.<\/jats:p>","DOI":"10.1111\/iep.12338","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T03:59:51Z","timestamp":1580270391000},"page":"350-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Hyponatraemia aggravates cardiac susceptibility to ischaemia\/reperfusion injury"],"prefix":"10.1111","volume":"100","author":[{"given":"Takahiro","family":"Oniki","sequence":"first","affiliation":[{"name":"Department of Cardiology and Clinical Examination Faculty of Medicine Oita University Yufu city Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2156-0598","authenticated-orcid":false,"given":"Yasushi","family":"Teshima","sequence":"additional","affiliation":[{"name":"Department of 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