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Male Wistar rats were randomly assigned to three groups: control (C), diabetic (DM) and diabetic treated with MSCs (DM\u2010MSCs). Diabetes was induced by streptozotocin (50\u00a0\u00b5g\/kg). Bone marrow cells were isolated from the tibia and femur. After 10\u00a0weeks of DM induction, the DM\u2010MSC rats received four i.p. injections of MSCs (1\u00a0\u00d7\u00a0106). Ten weeks after MSC transplantation, motor performance was evaluated by the rotarod test and the anterior tibial (TA) muscles were collected for morphometric and quantification of collagen birefringence by polarizing microscopy analysis. Motor performance of the DM group was significantly reduced when compared to the C group and increased significantly in the DM\u00a0+\u00a0MSC group. The TA muscle mass was significantly reduced in the DM and DM\u00a0+\u00a0MSC groups compared to the C group. The connective tissue increased in the DM group compared to the C group and decreased in the DM\u00a0+\u00a0MSC group. The percentage collagen birefringence decreased significantly in the DM group when compared to the C group and increased in the DM\u00a0+\u00a0MSC group. Motor performance was positively correlated with collagen birefringence and negatively correlated with percentage of connective tissue. The results indicate that MSC transplantation improves both motor function and the collagen macromolecular organization in type 1 DM.<\/jats:p>","DOI":"10.1111\/iep.12340","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T09:34:24Z","timestamp":1580981664000},"page":"359-368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of mesenchymal stromal cells on motor function and collagen in the skeletal muscles of rats with type I diabetes"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8339-664X","authenticated-orcid":false,"given":"Genoveva L. 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