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However, the role of microRNAs in distant organ reorganization at the premetastatic stage is less clear, although the process of premetastatic niche formation is a crucial event according to modern concepts of tumour dissemination. The role of the present study was to investigate the expression levels of miR\u2010155, miR\u201021, miR\u2010205 and miR\u2010let7b, as well as that of their target genes, in target organs of melanoma metastasis at the premetastatic stage. The expression levels of both the pro\u2010oncogenic miR\u2010155 and the tumour suppressive miR\u2010205 were found to be altered in the premetastatic liver of melanoma B16\u2010bearing mice. Bioinformatics analysis identified the target genes of miR\u2010155 to be nuclear factor, erythroid 2 like 2 (NFE2L2), secretogranin II, miR\u2010205, semaphorin 5A and vascular endothelial growth factor A (VEGFA). Among those, the redox status regulatory factor NFE2L2 was downregulated, which corresponded to increased levels of miR\u2010155. Due to the ability of pro\u2010oxidative events to initiate angiogenesis, VEGFA levels were evaluated in the premetastatic liver by immunohistochemistry, which revealed increased VEGFA expression in the central parts of the organ and diminished expression in the periphery. Taken together, these findings may support the concept of functional organ reorganization due to melanoma progression.<\/jats:p>","DOI":"10.1111\/iep.12342","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T12:21:04Z","timestamp":1581423664000},"page":"311-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["miR\u2010155 overexpression is followed by downregulation of its target gene, NFE2L2, and altered pattern of VEGFA expression in the liver of melanoma B16\u2010bearing mice at the premetastatic stage"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7660-700X","authenticated-orcid":false,"given":"Mariya B.","family":"Aksenenko","sequence":"first","affiliation":[{"name":"Departments of Pathophysiology Krasnoyarsk State Medical University Krasnoyarsk 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