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Hypertension also associates with non\u2010alcoholic fatty liver disease (NAFLD), which is becoming common due to a modern diet and lifestyle. The aim of the present study was to examine whether a high\u2010fat \"Western\" diet had effects on hypertension and associated NAFLD. Normotensive Wistar\u2010Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were placed on a normal chow or high\u2010fat diet for 8\u00a0weeks; blood pressure was measured fortnightly and body weight recorded weekly. As expected, SHR had elevated blood pressure compared to WKY. Diet did not influence blood pressure. Compared to SHR, WKY rats gained more weight, associating with increased white adipose tissue weight. Normotensive rats also had higher plasma cholesterol and triglycerides in response to a \u201cWestern\u201d diet, with no changes in plasma glucose levels. Neither strain developed atherosclerosis. Interestingly, high\u2010fat diet\u2010fed SHR had increased liver weight, associating with a significant level of hepatic lipid accumulation not observed in WKY. Further, they exhibited hepatocellular ballooning and increased hepatic inflammation, indicative of steatohepatitis. These findings suggest that a high\u2010fat \u201cWestern\u201d diet promotes features of NAFLD in SHR, but not WKY rats. Importantly, the high\u2010fat diet had no effect on blood pressure.<\/jats:p>","DOI":"10.1111\/iep.12369","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T09:49:26Z","timestamp":1597225766000},"page":"152-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A \u201cWestern Diet\u201d promotes symptoms of hepatic steatosis in spontaneously hypertensive rats"],"prefix":"10.1111","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1723-2679","authenticated-orcid":false,"given":"Si\u00e2n P","family":"Cartland","sequence":"first","affiliation":[{"name":"Heart Research Institute Sydney NSW Australia"},{"name":"Faculty of Health and Medicine University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Tamer","sequence":"additional","affiliation":[{"name":"Heart Research Institute Sydney NSW 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