{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:42:35Z","timestamp":1785930155157,"version":"3.56.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Fatty liver is the most common cause of liver disease, and its prevalence has been increasing globally. Colorectal cancer (CRC) accounts for approximately 10% of all cancers and metastasizes most commonly to the liver. Paget's \u2018Seed and Soil\u2019 theory of metastasis proposed that the secondary growth of cancer cells is dependent on the distal organ microenvironment. This implies that the risk of metastasis may change due to changes in the microenvironment of target organs. However, the association between steatosis, fatty change in the liver microenvironment, and liver metastasis has not been clarified. Here, we induced fatty liver conditions in BALB\/c mice using a choline\u2010deficient high\u2010fat diet with 0.1% methionine (CDAHFD) and then injected the CT26 cells to produce experimental metastasis. The number of metastatic tumours was significantly increased in mice with severe fatty liver as compared to control mice. The average size of metastatic tumours was smaller in mice with moderate fatty liver than in control mice. The stromal components, including cancer\u2010associated fibroblasts, tumour\u2010associated macrophages and tumour\u2010infiltrating lymphocytes, were also examined. Metastatic tumours in fatty liver showed invasive growth patterns without a fibrotic capsule. Compared to control groups, the polarization of macrophages and subtypes of tumour\u2010infiltrating lymphocytes differed depending on the extent of fatty liver progression. These results indicated that fatty changes in the liver influenced liver metastasis of CRC. Although moderate fatty changes suppress the growth of metastatic tumours in the liver, a severe fatty microenvironment may promote invasion and metastasis through alteration of the tumour microenvironment (TME).<\/jats:p>","DOI":"10.1111\/iep.12371","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T06:47:56Z","timestamp":1597214876000},"page":"162-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Fatty change of the liver microenvironment influences the metastatic potential of colorectal cancer"],"prefix":"10.1111","volume":"101","author":[{"given":"Satoshi","family":"Masaki","sequence":"first","affiliation":[{"name":"Department of Health and Science Prefectural University of Hiroshima Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Health and Science Prefectural University of Hiroshima Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoma","family":"Kunisho","sequence":"additional","affiliation":[{"name":"Department of Health and Science Prefectural University of Hiroshima Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kimoto","sequence":"additional","affiliation":[{"name":"Department of Health and Science Prefectural University of Hiroshima Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8743-3815","authenticated-orcid":false,"given":"Yasuhiko","family":"Kitadai","sequence":"additional","affiliation":[{"name":"Department of Health and Science Prefectural University of Hiroshima Hiroshima 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