{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:51:40Z","timestamp":1787014300578,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T00:00:00Z","timestamp":1609891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study compared the biological effect of Hesperidin, Mineral Trioxide Aggregate (MTA)\u2010Angelus and calcium hydroxide for direct pulp capping. A total of 126 dogs\n                    <jats:sup>,<\/jats:sup>\n                    teeth were divided according to the post\u2010treatment evaluation period into three groups (42 teeth each), group I: 2\u00a0weeks, group II: 4\u00a0weeks and group III: 8\u00a0weeks. Each group was further subdivided according to the pulp capping material into three subgroups (14 teeth each), subgroup A (Hesperidin), subgroup B (MTA\u2010Angelus) and subgroup C (Dycal). Both inflammatory response and dentine bridge formation were assessed by histopathology. All data were statistically analysed. Resolution of the inflammation was recorded by the time with a significant difference between subgroups\u00a0\u00a0 within the same group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.05). Hesperidin, MTA\u2010Angelus and Dycal showed either mild or moderate inflammation at 2\u00a0weeks with significant differences between subgroups (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05). At 4 and 8\u00a0weeks, there were no significant differences between subgroups (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a0.05). Absence of complete or partial calcified bridge with no odontoblastic layer was reported in all subgroups at 2\u00a0weeks while at 4\u00a0weeks, the majority of samples in Hesperidin and MTA subgroups showed amorphous calcified deposit. At 8\u00a0weeks, there was no significant difference (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&gt;\u00a0.05) between subgroups except that 78.5% and 92.9% of Hesperidin and MTA\u2010Angelus samples, respectively, showed moderate dentine bridge. Also, 78.5% of Hesperidin and Dycal samples revealed moderately thick dentine bridge while 78.7% of MTA\u2010Angelus showed a thin dentine bridge with a significant difference between them (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a0.05). In conclusion, Hesperidin is a promising pulp capping material inducing mild inflammation and good dentine bridge formation.\n                  <\/jats:p>","DOI":"10.1111\/iep.12385","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T23:45:47Z","timestamp":1610063147000},"page":"32-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Biological evaluation of hesperidin for direct pulp capping in dogs\u2019 teeth"],"prefix":"10.1111","volume":"102","author":[{"given":"Ebtesam O.","family":"Abo El\u2010Mal","sequence":"first","affiliation":[{"name":"Department of Endodontics Faculty of Dental and Oral Surgery Misr University for Science and Technology Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5466-2016","authenticated-orcid":false,"given":"Ashraf M.","family":"Abu\u2010Seida","sequence":"additional","affiliation":[{"name":"Department of Surgery, Anesthesiology &amp; Radiology Faculty of Veterinary Medicine Cairo University Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1277-2361","authenticated-orcid":false,"given":"Salma H.","family":"El Ashry","sequence":"additional","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.4103\/sej.sej_51_20","article-title":"Histopathological pulp response of dog's teeth capped with biosealer and biodentine: an in vivo study","volume":"10","author":"Al\u2010Sherbiny IM","year":"2020","journal-title":"Saudi Endod 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