{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:35:08Z","timestamp":1760369708237,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013318","name":"ShanXi Science and Technology Department","doi-asserted-by":"publisher","award":["201603D421021"],"award-info":[{"award-number":["201603D421021"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to investigate the effect of cell surface CD47 downregulation on ischaemia\u2010reperfusion injury (IRI) during pig liver transplantation. Blood samples were collected from healthy miniature Bama pigs randomly and equally divided into CD47 antagonism (group A), without CD47 antagonism (group B) and a sham group (group C). Blood samples were collected from groups A and B at 0, 8 and 48\u00a0hours after establishment of the new liver through an indwelling tube in the right internal jugular vein. Blood samples were collected at the same time points after liver dissociation from group C. The expression of interleukin\u20106 (IL\u20106) and tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) was detected by enzyme\u2010linked immunosorbent assay (ELISA); CD47 expression was detected by Western blot; and liver function indices, including alanine aminotransferase (ALT) and aspartic transaminase (AST), were directly read by an automatic biochemical analyzer. The concentrations of both receptors in group A were significantly lower than groups B and C, at 8 and 48\u00a0hours after establishment of blood flow. At 8 and 48\u00a0hours in the new liver stage, the values of CD47 levels, ALT and AST in group A were significantly reduced compared to groups B and C (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). The levels of CD47 in the three groups were consistent with the trends of the aforementioned observation indicators. The liver functions of the recipients were significantly improved by reducing the release of the inflammatory mediators. This study provides new ideas and intervention approaches for the treatment of IRI in liver transplantation.<\/jats:p>","DOI":"10.1111\/iep.12391","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T04:06:35Z","timestamp":1619064395000},"page":"140-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effects of cell surface CD47 downregulation on ischaemia\u2010reperfusion injury during pig liver transplantation"],"prefix":"10.1111","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0696-5618","authenticated-orcid":false,"given":"Zhi","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shanxi Provincial People\u2019s Hospital Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanxi Provincial People\u2019s Hospital Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shanxi Provincial People\u2019s Hospital Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010ni","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Health Statistics School of Public Health Shanxi Medical University Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Ohio State University College of Medicine Columbus OH USA"},{"name":"Wenzhou Central Hospital Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"188","article-title":"Liver transplantation in the treatment of primary liver cancer","volume":"37","author":"Yokoyama I","year":"1990","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.10.003"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(00)00573-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90583.2008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000259579.35787.4e"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605040200"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.24059"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.65"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0962-8924(00)01906-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.07.009"},{"issue":"7","key":"e_1_2_7_12_1","first-page":"1515","article-title":"Small interfering RNA\u2010induced suppression of MDR1 (P\u2010glycoprotein) restores sensitivity to multidrug\u2010resistant cancer cells","volume":"63","author":"Wu H","year":"2003","journal-title":"Cancer research"},{"issue":"7","key":"e_1_2_7_13_1","first-page":"493","article-title":"Prognosis and related risk factors in patients with primary liver cancer after liver transplantation [J]","volume":"25","author":"Lv S","year":"2019","journal-title":"Chinese Journal of Hepatobiliary Surgery"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000058744.34965.38"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2009.00591.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2010.03.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199205000-00004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.09.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M804860200"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.2.642"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.10.014"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-08-041368"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-098392"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945008785909310"},{"key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1096\/fasebj.31.1_supplement.469.6","article-title":"CD47 regulates CD11b\u2010dependent neutrophil transepithelial migration during intestinal inflammation","volume":"31","author":"Azcutia V","year":"2017","journal-title":"FASEB J"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.11.049"},{"key":"e_1_2_7_27_1","first-page":"76","article-title":"[Protective effect of ischemic preconditioning on hepatic state in its ischemic\u2010reperfusion injury]","volume":"4","author":"Oleshchuk OM","year":"2013","journal-title":"Klin Khir"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvu017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.173"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvu017"},{"issue":"4","key":"e_1_2_7_31_1","first-page":"1429","article-title":"Thrombospondin\u20101 receptor mediates autophagy of RAS\u2010expressing cancer cells and triggers tumour growth inhibition","volume":"33","author":"Kalas W","year":"2013","journal-title":"Anticancer Res"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300031"}],"container-title":["International Journal of Experimental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iep.12391","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T01:35:03Z","timestamp":1724895303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iep.12391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,21]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/iep.12391"],"URL":"https:\/\/doi.org\/10.1111\/iep.12391","archive":["Portico"],"relation":{},"ISSN":["0959-9673","1365-2613"],"issn-type":[{"type":"print","value":"0959-9673"},{"type":"electronic","value":"1365-2613"}],"subject":[],"published":{"date-parts":[[2021,4,21]]},"assertion":[{"value":"2020-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}