{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:23:07Z","timestamp":1772137387205,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014857","name":"National Natural Science Foundation of China-Guangdong Joint Fund","doi-asserted-by":"publisher","award":["81460037"],"award-info":[{"award-number":["81460037"]}],"id":[{"id":"10.13039\/501100014857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Xeroderma Pigmentosum group D (XPD) gene has been shown to suppress hepatocellular carcinoma (HCC) progression, but its mechanism remains not fully understood. ETS\u2010related gene (ERG) is generally known as an oncogenic gene. This study aimed to explore whether XPD regulated HCC cell proliferation, apoptosis and cell cycle by inhibiting ERG expression via the PPAR\u03b3 pathway. The human hepatoma cells (HepG2) were transfected with the XPD overexpression vector (pEGFP\u2010N2\/XPD) or empty vector (pEGFP\u2010N2). The PPAR\u03b3 inhibitor GW9662 was used to determine whether XPD effects were mediated by activation of PPAR\u03b3 pathway. Cell cycle and apoptosis were ascertained by flow cytometry, and cell viability was measured by MTT assay. Reverse transcription\u2010polymerase chain reaction and Western blot were performed to determine the mRNA and protein levels. Overexpression of XPD significantly enhanced the expression of PPAR\u03b3 and p\u2010PPAR\u03b3, whereas it downregulated that of ERG and cdk7. Furthermore, XPD overexpression notably inhibited proliferation, promoted apoptosis and decreased the percentage of cells in the S\u00a0+\u00a0G2 phase of HepG2 cells. However, these effects of XPD overexpression were abrogated by GW9662. Collectively, XPD suppresses proliferation and promotes apoptosis of HepG2 cells by downregulating ERG expression via activation of the PPAR\u03b3 pathway.<\/jats:p>","DOI":"10.1111\/iep.12396","type":"journal-article","created":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T06:45:45Z","timestamp":1621147545000},"page":"157-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Xeroderma Pigmentosum group D suppresses proliferation and promotes apoptosis of HepG2 cells by downregulating ERG expression via the PPAR\u03b3 pathway"],"prefix":"10.1111","volume":"102","author":[{"given":"Yue","family":"He","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqiang","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of ICU The First Affiliated 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