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Thromboxane A<jats:sub>2<\/jats:sub> (TXA<jats:sub>2<\/jats:sub>) not only induces platelet activity but also angiogenesis. This study investigated the role of TXA<jats:sub>2<\/jats:sub> in gastric ulcer healing using TXA<jats:sub>2<\/jats:sub> receptor knockout (TPKO) mice. Gastric ulcer healing was suppressed by treatment with the TXA<jats:sub>2<\/jats:sub> synthase inhibitor OKY\u2010046 and the TXA<jats:sub>2<\/jats:sub> receptor antagonist S\u20101452 compared with vehicle\u2010treated mice. TPKO showed delayed gastric ulcer healing compared with wild\u2010type mice (WT). The number of microvessels and CD31 expression were lower in TPKO than in WT mice, and TPKO suppressed the expression of transforming growth factor beta (TGF\u2010\u03b2) and vascular endothelial growth factor A (VEGF\u2010A) in areas around gastric ulcers. Immunofluorescence assays showed that TGF\u2010\u03b2 and VEGF\u2010A co\u2010localized with platelets. 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