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Since <jats:italic>Danio rerio<\/jats:italic> is a promising animal model to study gut function, we developed a soy\u2010dependent model of intestinal inflammation in adult zebrafish. The soya bean meal diet was given for 4\u00a0weeks and induced an inflammatory process, as demonstrated by morphological changes together with an increased percentage of neutrophils infiltrating the intestinal wall, which developed between the second and fourth week of treatment. Pro\u2010inflammatory genes such as interleukin\u20101beta, interleukin\u20108 and tumour necrosis factor alpha were upregulated in the second week and anti\u2010inflammatory genes such as transforming growth factor beta and interleukin\u201010. Interestingly, an additional expression peak was found for interleukin\u20108 at the fourth week. Neuronal genes, OTX1 and OTX2, were significantly upregulated in the first two \u00a0weeks, compatible with the development of the changes in the gut wall. As for the genes of the p53 family such as p53, DNp63 and p73, a statistically significant increase was observed after two\u00a0weeks of treatment compared with controls. Interestingly, DNp63 and p73 were shown an additional peak after four\u00a0weeks. Our data demonstrate that soya bean meal diet negatively influences intestinal morphology and immunological function in adult zebrafish showing the features of acute inflammation. Data observed at the fourth week of treatment may suggest initiation of chronic inflammation. Adult zebrafish may represent a promising model to better understand the mechanisms of food\u2010dependent intestinal inflammation.<\/jats:p>","DOI":"10.1111\/iep.12420","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T06:32:19Z","timestamp":1635834739000},"page":"13-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Soy diet induces intestinal inflammation in adult Zebrafish: Role of OTX and P53 family"],"prefix":"10.1111","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7666-5311","authenticated-orcid":false,"given":"Giovanni","family":"Micheloni","sequence":"first","affiliation":[{"name":"Centro di Medicina Genomica Department of Medicine and Surgery University of Insubria Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Carnovali","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico 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