{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:58:38Z","timestamp":1783479518934,"version":"3.55.0"},"reference-count":67,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EEQ\/2016\/000345"],"award-info":[{"award-number":["EEQ\/2016\/000345"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vasculogenic mimicry (VM), an endothelial cell\u2013independent alternative mechanism of blood supply to the malignant tumour, has long been considered as an adverse prognostic factor in many cancers. The correlation of VM with laminin\u20105\u03b32 and the assessment of their harmonized expression as an independent risk factor have not been elucidated yet in oral squamous cell carcinoma (OSCC). CD31\/PAS staining stratified 116 clinically diagnosed OSCC specimens into VM+ and VM\u2212 cohorts. The expression pattern of laminin\u20105\u03b32 and its upstream modulator MMP2 was evaluated by immunohistochemistry and Western blot. The Kaplan\u2013Meier and Cox regression analyses were performed to assess the survival and prognostic implications. The presence of VM demonstrated a significant correlation with the expression of laminin\u20105\u03b32 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) and MMP2 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). This pattern was mirrored by the significant upregulation of laminin\u20105\u03b32 and MMP2 in VM+ cohorts compared with the VM\u2212 ones. Furthermore, co\u2010expression of VM and laminin\u20105\u03b32 was significantly associated with tumour grade (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.010), primary tumour size (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), lymph node metastasis (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) and TNM stages (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) but not with patients' age, gender, tobacco and alcohol consumption habit. Vasculogenic mimicry and laminin\u20105\u03b32 double\u2010positive cohort displayed a significantly poorer disease\u2010free survival (DFS) and overall survival (OS). Vasculogenic mimicry, laminin\u20105\u03b32 and their subsequent dual expression underlie a significant prognostic value for DFS [hazard ratio (HR)\u00a0=\u00a09.896, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.028] and OS [HR\u00a0=\u00a021.401, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.033] in OSCC patients. Together, our findings imply that VM along with laminin\u20105\u03b32 is strongly linked to the malignant progression in OSCC and VM and laminin\u20105\u03b32 coordination emerges as a critical prognostic biomarker for OSCC.<\/jats:p>","DOI":"10.1111\/iep.12430","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T12:05:27Z","timestamp":1645013127000},"page":"54-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Orchestrated expression of vasculogenic mimicry and laminin\u20105\u03b32 is an independent prognostic marker in oral squamous cell carcinoma"],"prefix":"10.1111","volume":"103","author":[{"given":"Depanwita","family":"Saha","sequence":"first","affiliation":[{"name":"Department of Signal Transduction and Biogenic Amines Chittaranjan National Cancer Institute  Kolkata 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