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In this study, 18 Wistar albino young\u2013adult breastfeeding mothers with their offspring were divided into three groups: control group, low\u2010dose MCP\u2010applied group and high\u2010dose MCP\u2010applied group. The experiment was carried out during the lactation period and at the end of 21\u00a0days. Prolactin, BrdU and Ki\u201067 breast tissue distributions were evaluated by immunohistochemistry, and tissue levels were evaluated biochemically by the ELISA method. According to ELISA and immunohistochemistry results in breast tissue, there was no significant difference between Ki\u201067 and BrdU results in all groups. Metoclopramide did not change the expression of proliferation molecules Ki\u201067 and BrdU in breast tissue. These results suggested that while metoclopramide increases breast proliferation, it does not have the risk of transforming the tissue into a tumour.<\/jats:p>","DOI":"10.1111\/iep.12433","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:53:56Z","timestamp":1646355236000},"page":"83-89","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the effect of metoclopramide on proliferation signal molecules in breast tissue"],"prefix":"10.1111","volume":"103","author":[{"given":"Nurcan","family":"Umur","sequence":"first","affiliation":[{"name":"Department of Molecular Biology School of Vocational Health Service Manisa Celal Bayar University Manisa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selda","family":"\u0130ldan \u00c7al\u0131m","sequence":"additional","affiliation":[{"name":"Department of Midwifery Faculty of Health Sciences Manisa Celal 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