{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:05:52Z","timestamp":1789164352007,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760334"],"award-info":[{"award-number":["81760334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Autophagy has been implicated in the pathogenesis of various lung diseases. This study aimed to investigate the role of autophagy in lung injury induced by high\u2010altitude hypoxia. Wistar rats were randomized into four groups for exposure to normal altitude or high altitude for 1, 7, 14 and 21\u00a0days with no treatment or with the treatment of 1\u00a0mg\/kg rapamycin or 2\u00a0mg\/kg 3\u2010methyladenine (3\u2010MA) for consecutive 21\u00a0days respectively. In control rats, the alveolar structure was intact with regularly arranged cells. However, inflammatory cell infiltration and shrunk alveoli were observed in rats exposed to hypoxia. Rapamycin treatment led to many shrunken alveoli with a large number of red blood cells in them. In contrast, 3\u2010MA treatment led to almost intact alveoli or only a few shrunken alveoli. Compared to the control group exposure to high\u2010altitude hypoxia for longer periods resulted in the aggravation of the lung injury, the formation of autophagosomes with a double\u2010membrane structure and increased levels of Beclin\u20101 and LC3\u2010II in alveolar tissues. Rapamycin treatment resulted in significant increase in Beclin\u20101 and LC3\u2010II levels and further aggravation of alveolar tissue damage, while 3\u2010MA treatment led to opposite effects. In conclusion, exposure to high\u2010altitude hypoxia can induce autophagy of alveolar cells, which may be an important mechanism of high\u2010altitude hypoxia\u2010induced lung injury. The inhibition of autophagy may be a promising therapy strategy for high\u2010altitude hypoxia\u2010induced lung injury.<\/jats:p>","DOI":"10.1111\/iep.12434","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T10:55:33Z","timestamp":1646218533000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High\u2010altitude hypoxia\u2010induced rat alveolar cell injury by increasing autophagy"],"prefix":"10.1111","volume":"103","author":[{"given":"Zhen","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Wuxi Huishan District People\u2019s Hospital  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Qinghai Provincial People\u2019s Hospital  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Wuxi Huishan District People\u2019s Hospital  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Wuxi Huishan District People\u2019s Hospital  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Qinghai Provincial People\u2019s Hospital  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanzhuan","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Wuxi Huishan District People\u2019s Hospital  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5628-6939","authenticated-orcid":false,"given":"Jie","family":"Duo","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Qinghai Provincial People\u2019s Hospital  Xining China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c100029"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12063"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090594"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06639"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.12.010"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.11.001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12357"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600265"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00527.2016"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.11.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6277"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455953"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eoaa052"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddab139"},{"key":"e_1_2_7_16_1","first-page":"36","article-title":"T\u03b24 contributes to survival and microvessels formation of endothelial progenitor cells via MAPK\/ERK pathway","volume":"1","author":"Yang Q","year":"2021","journal-title":"J Comp Mol Sci Genet"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.06.016"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.32604\/biocell.2020.011642"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.01.059"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2886"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.32604\/biocell.2020.09639"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4623"}],"container-title":["International Journal of Experimental Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12434","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iep.12434","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iep.12434","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T21:30:22Z","timestamp":1692826222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iep.12434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1111\/iep.12434"],"URL":"https:\/\/doi.org\/10.1111\/iep.12434","archive":["Portico"],"relation":{},"ISSN":["0959-9673","1365-2613"],"issn-type":[{"value":"0959-9673","type":"print"},{"value":"1365-2613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,2]]},"assertion":[{"value":"2021-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}