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The mdx mouse is one of the most widely used experimental models to understand aspects of the biology of dystrophic skeletal muscles and the mechanisms of DMD. Oxidative stress and apoptosis are present in early stages of the disease in mdx mice. The high production of reactive oxygen species (ROS) causes activation of apoptotic death regulatory proteins due to DNA damage and breakdown of nuclear and mitochondrial membranes. The quadriceps (QUA) muscle of the mdx mouse is a good tool to study oxidative events. Previous studies have demonstrated that cilostazol exerts an anti\u2010oxidant effect by decreasing the production of reactive oxygen species (ROS). The present study aimed to evaluate the ability of cilostazol to modulate oxidative stress and apoptosis in the QUA muscle of mdx mice. Fourteen\u2010day\u2010old mdx mice received cilostazol or saline for 14\u2009days. C57BL\/10 mice were used as a control. In the QUA muscle of mdx mice, cilostazol treatment decreased ROS production (\u221274%), the number of lipofuscin granules (\u221247%), lipid peroxidation (\u221211%), and the number of apoptotic cells (\u221266%). Thus cilostazol showed anti\u2010oxidant and anti\u2010apoptotic action in the QUA muscle of mdx mice.<\/jats:p>","DOI":"10.1111\/iep.12461","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T10:00:13Z","timestamp":1671876013000},"page":"13-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cilostazol attenuates oxidative stress and apoptosis in the quadriceps muscle of the dystrophic mouse experimental model"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2937-3890","authenticated-orcid":false,"given":"T\u00falio de Almeida","family":"Hermes","sequence":"first","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology State University of Campinas (UNICAMP)  S\u00e3o Paulo Brazil"},{"name":"Departament of Anatomy, Institute of Biomedical Sciences Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas 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