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A total of 3956 DCB were found in the 139 TA: 98% were in asymmetric branching (DCAB) and the remaining 2% in symmetric branching (DCSB). A linear correlation was found between DCB frequency and the increasing digital size in TA (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). Using a digital ruler, adenomas were divided into small TA (&lt;5\u2009mm) and larger TA (\u22655\u2009mm). The difference between the frequency of DCB in small TA (<jats:italic>n<\/jats:italic>\u00a0=\u00a075) vs. larger TA (<jats:italic>n<\/jats:italic>\u00a0=\u00a064), was significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05). DCB frequency was not influenced by age, gender or TA localization. In the normal colorectal mucosa (\u22482 m<jats:sup>2<\/jats:sup>), only occasional CSB is found and no CAB. And yet, multiple DCB (mean 16.7 DCB), mostly DCAB, was found in small TA, occupying &lt;5\u2009mm of the mucosal area. In larger TA, as many as 42.1 DCB (mean), mostly DCAB, occurred in merely 7.8\u2009mm (mean) of the colon mucosa. Thus it is suggested\u00a0that DCB is a standard histologic element of TA. The natural expansion of the adenomatous tissue in larger TA appears to be follow on from newly produced, mostly DCAB, by DCSB and by the accumulation of their dysplastic offspring's progenies. The findings strongly suggest that DCB is a central microstructure in the histological events unfolding in polypoid colorectal TA.<\/jats:p>","DOI":"10.1111\/iep.12466","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T14:09:39Z","timestamp":1675433379000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The frequency of dysplastic branching crypts in colorectal polypoid tubular adenomas"],"prefix":"10.1111","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3879-5729","authenticated-orcid":false,"given":"Carlos A.","family":"Rubio","sequence":"first","affiliation":[{"name":"Department of Pathology, Karolinska Institute University Hospital  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Vieth","sequence":"additional","affiliation":[{"name":"Institute of Pathology Friedrich\u2010Alexander\u2010University Erlangen\u2010Nuremberg  Bayreuth Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Lang\u2010Schwarz","sequence":"additional","affiliation":[{"name":"Institute of Pathology Friedrich\u2010Alexander\u2010University Erlangen\u2010Nuremberg  Bayreuth Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"78","article-title":"De excrentiis verracosocristasis","volume":"9","author":"Mentzel D","year":"1721","journal-title":"Acta Med Berlin"},{"key":"e_1_2_9_3_1","first-page":"165","article-title":"Two cases of disseminated polyps of the rectum","volume":"33","author":"Cripps WH","year":"1882","journal-title":"Trans Pathol Soc London"},{"key":"e_1_2_9_4_1","first-page":"250","article-title":"Innocent tumours of the rectum and colon: President's address","volume":"20","author":"Lockhart\u2010Mummery JP","year":"1927","journal-title":"Proc R Soc Med"},{"key":"e_1_2_9_5_1","first-page":"591","article-title":"Dukes C the precancerous changes in the rectum and colon","volume":"46","author":"Lockhart\u2010Mummery JP","year":"1928","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1939.02800470003002"},{"key":"e_1_2_9_7_1","first-page":"327","article-title":"The adenoma\u2010carcinoma sequence in cancer of the colon","volume":"93","author":"Jackman RJ","year":"1951","journal-title":"Surg Gynec Obst"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1962.03050050006002"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-195810000-00014"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820360644"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-018-0642-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000042256.89282.c4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63652-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-019-0801-3"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iep.12432"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600561113"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt191"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.259"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711570304"},{"key":"e_1_2_9_20_1","first-page":"6973","article-title":"p53 up\u2010regulation during colorectal carcinogenesis","volume":"34","author":"Rubio CA","year":"2014","journal-title":"Anticancer Res"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220353110"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00310"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03119.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02603423"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199807)185:3<246::AID-PATH90>3.0.CO;2-8"},{"volume-title":"Familial Polyposis Coli. 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