{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:27:24Z","timestamp":1788787644498,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["241312"],"award-info":[{"award-number":["241312"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["A1\u2010S\u201021375 (MMO)"],"award-info":[{"award-number":["A1\u2010S\u201021375 (MMO)"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["221262 (AQS)"],"award-info":[{"award-number":["221262 (AQS)"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Experimental Path"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Arginine vasopressin (AVP) is a naturally occurring hormone synthesized in the hypothalamus. AVP demonstrates pro\u2010fibrotic effects as it stimulates hepatic stellate cells to secrete transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) and collagen. Previous work in liver cirrhotic (CCL\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced) hamsters demonstrated that AVP deficiency induced by neurointermediate pituitary lobectomy (NIL) can restore liver function. Therefore, we hypothesized that liver fibrosis would decrease in portocaval anastomosis (PCA) rats, which model chronic liver diseases, when they are treated with the V1a\u2013V2 AVP receptor antagonist conivaptan (CV). In this study, changes in liver histology and gene expression were analysed in five experimental groups: control, PCA, NIL, PCA\u2009+\u2009NIL and PCA\u2009+\u2009CV, with NIL surgery or CV treatment administered 8\u2009weeks after PCA surgery. Body weight gain was assessed on a weekly basis, and serum liver function, liver weight and liver glycogen content were assessed following euthanasia. Most PCA\u2010induced phenotypes were reverted to normal levels following AVP\u2010modelled deficiency, though hypoglycemia and ammonium levels remained elevated in the PCA\u2009+\u2009CV group. Liver histopathological findings showed a significant reversal in collagen content, less fibrosis in the triad and liver septa and increased regenerative nodules. Molecular analyses showed that the expression of fibrogenic genes (TGF\u2010\u03b2 and collagen type I) decreased in the PCA\u2009+\u2009CV group. Our findings strongly suggest that chronic NIL or CV treatment can induce a favourable microenvironment to decrease liver fibrosis and support CV as an alternative treatment for liver fibrosis.\n                  <\/jats:p>","DOI":"10.1111\/iep.12476","type":"journal-article","created":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T15:41:04Z","timestamp":1679758864000},"page":"209-222","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Arginine vasopressin deficiency and conivaptan (a V1a\u2013V2 receptor antagonist) treatment reverses liver damage and fibrosis in rats with chronic portocaval anastomosis"],"prefix":"10.1111","volume":"104","author":[{"given":"Yesenia Danyeli","family":"Navarro\u2010Gonzalez","sequence":"first","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas Universidad Aut\u00f3noma de Aguascalientes  Aguascalientes 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Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argelia","family":"Calvillo\u2010Robedo","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas Universidad Aut\u00f3noma de Aguascalientes  Aguascalientes Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel\u2010Enrique","family":"Avila\u2010Blanco","sequence":"additional","affiliation":[{"name":"Departamento de Morfolog\u00eda, Centro de Ciencias B\u00e1sicas Universidad Aut\u00f3noma de Aguascalientes  Aguascalientes Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Valdez\u2010Urias","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas Universidad Aut\u00f3noma de Aguascalientes  Aguascalientes 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