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The flavonoid trilobatin (TLB) demonstrates antioxidant and anti\u2010inflammatory potential. Its high safety profile and effective action make it a potent therapy for the process of dystrophic muscle myonecrosis. Thus, we sought to investigate the action of TLB on damage in a DMD model, the mdx mouse. Eight\u2010week\u2010old male animals were treated with 160\u2009mg\/kg\/day of trilobatin for 8\u2009weeks. Control animals were treated with saline. Following treatment, muscle strength, serum creatine kinase (CK) levels, histopathology (necrotic myofibres, regenerated fibres\/central nuclei, Feret's diameter and inflammatory area) and the levels of catalase and NF\u2010\u03baB (western blotting) of the quadriceps (QUA), diaphragm (DIA) and tibialis anterior (TA) muscles were measured. TLB was able to significantly increase muscle strength and reduce serum CK levels in dystrophic animals. The QUA of mdx mice showed a reduction in catalase and the number of fibres with a centralized nucleus after treatment with TLB. In the DIA of dystrophic animals, TLB reduced the necrotic myofibres, inflammatory area and NF\u2010\u03baB and increased the number of regenerated fibres and the total fibre diameter. In TA, TLB increased the number of regenerated fibres and reduced catalase levels in these animals. It is concluded that in the mdx experimental model, treatment with TLB was beneficial in the treatment of DMD.<\/jats:p>","DOI":"10.1111\/iep.12502","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T12:20:53Z","timestamp":1710332453000},"page":"75-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Trilobatin contributes to the improvement of myopathy in a mouse model of Duchenne muscular dystrophy"],"prefix":"10.1111","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2937-3890","authenticated-orcid":false,"given":"T\u00falio de Almeida","family":"Hermes","sequence":"first","affiliation":[{"name":"Department of Anatomy, ICB Federal University of Alfenas (UNIFAL\u2010MG)  Alfenas Minas Gerais 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